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Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis:A Population-Based Study in the Netherlands

Authors :
van Broekhoven, Danique L M
Verschoor, Arie J
van Dalen, Thijs
Grünhagen, Dirk J
den Bakker, Michael A
Gelderblom, Hans
Bovee, Judith V M G
Haas, Rick L M
Bonenkamp, Han J
van Coevorden, Frits
Ten Oever, Diederik
van der Graaf, Winette T A
Flucke, Uta E
Pras, Elisabeth
Reyners, Anna K L
Westermann, Anneke M
Oldenburger, Foppe
Verhoef, Cornelis
Steeghs, Neeltje
van Broekhoven, Danique L M
Verschoor, Arie J
van Dalen, Thijs
Grünhagen, Dirk J
den Bakker, Michael A
Gelderblom, Hans
Bovee, Judith V M G
Haas, Rick L M
Bonenkamp, Han J
van Coevorden, Frits
Ten Oever, Diederik
van der Graaf, Winette T A
Flucke, Uta E
Pras, Elisabeth
Reyners, Anna K L
Westermann, Anneke M
Oldenburger, Foppe
Verhoef, Cornelis
Steeghs, Neeltje
Source :
van Broekhoven , D L M , Verschoor , A J , van Dalen , T , Grünhagen , D J , den Bakker , M A , Gelderblom , H , Bovee , J V M G , Haas , R L M , Bonenkamp , H J , van Coevorden , F , Ten Oever , D , van der Graaf , W T A , Flucke , U E , Pras , E , Reyners , A K L , Westermann , A M , Oldenburger , F , Verhoef , C & Steeghs , N 2018 , ' Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis : A Population-Based Study in the Netherlands ' , Sarcoma , vol. 2018 , 5982575 .
Publication Year :
2018

Abstract

INTRODUCTION: Nonsurgical management of patients with desmoid-type fibromatosis (DF) is increasing. This study tries to provide insight on type, usage, and outcome of first-line nonsurgical management strategies.PATIENTS AND METHODS: From the Dutch Pathology Registry (PALGA), patients with extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 and 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start of treatment/surveillance until change of treatment or last follow-up was analyzed.RESULTS: Ninety-one of the 1141 identified patients had first-line nonsurgical management. The percentage of patients treated nonsurgically increased from 0.6% in 1993-1998 to 12.8% in 2009-2013. Thirty-seven patients had surveillance (41%), 35 radiotherapy (38%), and 19 systemic treatment (21%). BR for surveillance was complete response (CR) in 2/37, partial response (PR) in 4/37, stable disease (SD) in 21/37, progressive disease (PD) in 5/37, and unknown in 5/37 patients. BR for radiotherapy was CR in 4/35, PR in 11/35, SD in 16/35, and unknown in 4/35. BR for systemic treatment was CR in 1/19, PR in 1/19, SD in 10/19, PD in 2/19, and unknown in 5/19. Totally, 91% of patients did not progress.DISCUSSION: Given the low percentage (9%) of PD of nonsurgical management, these data can be used in shared decision making with the patient regarding optimal treatment.

Details

Database :
OAIster
Journal :
van Broekhoven , D L M , Verschoor , A J , van Dalen , T , Grünhagen , D J , den Bakker , M A , Gelderblom , H , Bovee , J V M G , Haas , R L M , Bonenkamp , H J , van Coevorden , F , Ten Oever , D , van der Graaf , W T A , Flucke , U E , Pras , E , Reyners , A K L , Westermann , A M , Oldenburger , F , Verhoef , C & Steeghs , N 2018 , ' Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis : A Population-Based Study in the Netherlands ' , Sarcoma , vol. 2018 , 5982575 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1376781069
Document Type :
Electronic Resource