Back to Search Start Over

Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting

Authors :
Brioschi, M
Gianazza, E
Andreini, D
Mushtaq, S
Cavallotti, L
Veglia, F
Tedesco, C
Colombo, G
Pepi, M
Polvani, G
Tremoli, E
Parolari, A
Banfi, C
Brioschi M.
Gianazza E.
Andreini D.
Mushtaq S.
Cavallotti L.
Veglia F.
Tedesco C. C.
Colombo G. I.
Pepi M.
Polvani G.
Tremoli E.
Parolari A.
Banfi C.
Brioschi, M
Gianazza, E
Andreini, D
Mushtaq, S
Cavallotti, L
Veglia, F
Tedesco, C
Colombo, G
Pepi, M
Polvani, G
Tremoli, E
Parolari, A
Banfi, C
Brioschi M.
Gianazza E.
Andreini D.
Mushtaq S.
Cavallotti L.
Veglia F.
Tedesco C. C.
Colombo G. I.
Pepi M.
Polvani G.
Tremoli E.
Parolari A.
Banfi C.
Publication Year :
2022

Abstract

Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative stress is currently considered to be a potential contributor. Human serum albumin (HSA) represents the main antioxidant in plasma through its reduced amino acid Cys34, which can efficiently scavenge several oxidants. In a nested case-control study including 36 patients with occluded grafts and 38 age- and sex-matched patients without occlusion, we assessed the levels of the native mercaptoalbumin (HSA-SH) and oxidized thiolated form of albumin (Thio-HSA) in relation with graft occlusion within 5 years after CABG. We found that the plasma level of preoperative HSA-SH was significantly lower in patients with occluded graft at 5 years follow-up than in patients with graft patency. Furthermore, low HSA-SH remained independently associated with graft occlusion even after adjusting for preoperative D-dimer, a well-known marker of activated coagulation recently found to be associated with graft occlusion. In conclusion, the preoperative level of HSA-SH is independently associated with graft occlusion in CABG and represents a measurable and potentially druggable predictor.

Details

Database :
OAIster
Notes :
ELETTRONICO, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1376721077
Document Type :
Electronic Resource