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Diagnostic Accuracy of Cell Block Preparations and Clinical Features Affecting It in Vitreoretinal Lymphoma

Authors :
1000060374394
Kase, Satoru
1000070333599
Namba, Kenichi
1000070374402
Iwata, Daiju
1000080598780
Mizuuchi, Kazuomi
Suzuki, Kayo
Ito, Takako
Hase, Keitaro
Kitaichi, Nobuyoshi
1000010245558
Ishida, Susumu
1000060374394
Kase, Satoru
1000070333599
Namba, Kenichi
1000070374402
Iwata, Daiju
1000080598780
Mizuuchi, Kazuomi
Suzuki, Kayo
Ito, Takako
Hase, Keitaro
Kitaichi, Nobuyoshi
1000010245558
Ishida, Susumu
Publication Year :
2022

Abstract

Purpose: The purpose of this study was to examine the diagnostic accuracy of the cell block (CB) method and clinical features affecting it in patients with vitreoretinal lymphoma (VRL). Methods: This study enrolled 38 eyes in 33 VRL patients, and 7 eyes in 7 patients with idiopathic uveitis who underwent diagnostic vitrectomy. Medical records including the results of CB cytology, interleukin (IL)-10/-6 concentrations, and immunoglobulin heavy chain gene (IgH) rearrangement were retrospectively searched. Results: Patients with VRL comprised 16 women and 17 men, and the age of onset ranged from 44 to 85 years (mean: 70 years). CB preparations detected large malignant cells in 35 eyes (92%), whereas the other 3 VRL eyes were negative. Two of the latter three eyes showed subretinal infiltrates, which existed in 7 of 35 CB-positive eyes. Intravitreal IL-10 and -6 concentrations were 1866 +/- 4088 pg/mL and 98 +/- 139 pg/mL, respectively, and the rate of IL-10/-6 >1 was 86.9%. The presence of IgH monoclonality was 63.2%. In patients with uveitis, CB specimens revealed no atypical but small inflammatory cells. IL-6 concentration was 311.1 +/- 240 pg/mL, whereas IL-10 was undetectable in six eyes, and the IL-negative rate was 85.7%. Six eyes (85.7%) with uveitis showed no IgH monoclonality. Conclusions: Diagnostic accuracy of CB preparations in VRL could achieve an equivalent outcome to IL ratio calculation and IgH monoclonality detection. The appearance of subretinal infiltrates may diminish the CB positivity.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1375184350
Document Type :
Electronic Resource