Heart failure with preserved ejection fraction : from comorbidities to endothelial dysfunction, exploring the road through inflammation and oxidative stress

Heart failure with preserved ejection fraction is defined by the presence of symptoms of heart failure in the absence of a reduced left ventricular ejection fraction. The heart suffers from an impaired relaxation, leading to elevated filling pressures. This results in shortness of breath, congestion, and exercise intolerance with significant impact on the patient's quality of life and prognosis. The pathophysiological mechanisms are not yet fully elucidated but it now seems clear that the pro-inflammatory state and oxidative stress linked to the presence of metabolic comorbidities, such as obesity and diabetes, plays a key role in the development of the disease. The objective of this work is to better characterize these patients, particularly according to their metabolic profile, and to explore the pathophysiological mechanisms underlying different profiles.
(MED - Sciences médicales) -- UCL, 2022