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The Role of NLRP3 Inflammasome Signaling on Arrhythmias in Diabetes
- Publication Year :
- 2022
-
Abstract
- Lei Zhang,1,* Huan-Huan Liu,2,* Feng Li,1 Fan Yang,1 Ling-Ling Qian,1 Ru-Xing Wang1 1Department of Cardiology, Wuxi Peopleâs Hospital Affiliated to Nanjing Medical University, Wuxi, Peopleâs Republic of China; 2Wuxi School of Medicine, Jiangnan University, Wuxi, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Ru-Xing Wang, Tel +86-510-85351593, Fax +86-510-85350555, Email ruxingw@aliyun.comAbstract: Diabetes is a significant risk factor for arrhythmias. However, the pathophysiology of diabetes-related arrhythmias still needs to be elucidated, presumably associated with structural and electrical remodeling. There is growing evidence that inflammation and arrhythmias are intimately associated, which has spurred significant interest in exploring the regulatory links in diabetes. Recent research findings have revealed a vital role for the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signaling, and facilitated the occurrence of arrhythmias in diabetes, including NLRP3 inflammasome activation by multiple stressors and its downstream cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18). This narrative review aims to summarize the complex interaction between NLRP3 inflammasomes signaling and diabetes-related arrhythmias. Articles regarding the role of NLRP3 inflammasome in diabetes-related arrhythmias and relevant mechanisms were selected. Relevant articles were selected from PubMed. The search terms were âNLRP3 inflammasomeâ and âdiabetesâ and âarrhythmiaâ. Important references from selected articles were also retrieved. The role of NLRP3 inflammasome signaling in diabetes-induced arrhythmias may provide a new option for the prevention and treatment diabetes-related arrhythmias.Keywords: NLRP3, inflammasome, diabetes, arrhythmia
Details
- Database :
- OAIster
- Notes :
- text/html, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1370327121
- Document Type :
- Electronic Resource