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Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia.
- Source :
- Movement disorders clinical practice; vol 9, iss 4, 479-483; 2330-1619
- Publication Year :
- 2022
-
Abstract
- BackgroundThe criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.MethodsThe MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD-MCI (n = 467). Risk for developing PDD was examined using a Cox model. Global cognitive tests were compared to neuropsychological test batteries (Level I&II) in determining risk for PDD.ResultsPD-MCI based on a global cognitive test (MMSE or MoCA) increases the hazard for developing PDD (respectively HR = 2.57, P = 0.001; HR = 4.14, P = <0.001). The C-statistics for MMSE (0.72) and MoCA (0.70) were lower than those based on neuropsychological tests (Level I = 0.82; Level II = 0.81). Sensitivity, specificity and diagnostic accuracy balance was best in Level II.ConclusionMMSE and MoCA predict conversion to PDD. However, Level II neuropsychological assessment seems the preferred assessment for PD-MCI.
Details
- Database :
- OAIster
- Journal :
- Movement disorders clinical practice; vol 9, iss 4, 479-483; 2330-1619
- Notes :
- application/pdf, Movement disorders clinical practice vol 9, iss 4, 479-483 2330-1619
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1367389886
- Document Type :
- Electronic Resource