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Calciphylaxis in chronic kidney disease
- Source :
- Giornale di Clinica Nefrologica e Dialisi; Vol. 28 No. 2 (2016): April-June 2016; 102-104; Giornale di Clinica Nefrologica e Dialisi; V. 28 N. 2 (2016): Aprile-Giugno 2016; 102-104; 2705-0076; 10.5301/GTND.2016.15749
- Publication Year :
- 2016
-
Abstract
- Purpose: Calciphylaxis or Calcific Uraemic Arteriolopathy (CUA) is a rare systemic disorder associated with endstage renal disease and carrying a very poor prognosis and high mortality. It is characterized by skin necrosis and gangrene secondary to thrombosis and calcification of dermo-epidermal arterioles. Pathogenetic mechanisms inducing calciphylaxis are for the most part unknown. Methods: We report a case of calciphylaxis in a patient on long-term haemodialysis with severe secondary hyperparathyroidism. Despite therapies for hyperparathyroidism, the injury healed only after parathyroidectomy. Results: Calciphylaxis is an obliterative vasculopathy. The role of severe hyperparathyroidism in the pathogenesis of calciphylaxis is not well understood. A unique feature is the phenotypic differentiation of smooth muscle cells into osteoid-like cells. The vascular smooth muscle cells, exposed to high inorganic phosphate levels, could be transformed into osteoblast-like cells in patients undergoing haemodialysis with a poor control of phosphate intake. Conclusions: The uraemic condition contributes to vascular smooth muscle cell apoptosis and differentiation into bone forming osteoblast-like cells resulting in medial calcification. Nowadays no effective treatments are available for the successful management of calciphylaxis.<br />non disponibile
Details
- Database :
- OAIster
- Journal :
- Giornale di Clinica Nefrologica e Dialisi; Vol. 28 No. 2 (2016): April-June 2016; 102-104; Giornale di Clinica Nefrologica e Dialisi; V. 28 N. 2 (2016): Aprile-Giugno 2016; 102-104; 2705-0076; 10.5301/GTND.2016.15749
- Notes :
- application/pdf, Italian
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1367176315
- Document Type :
- Electronic Resource