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Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis
- Source :
- The Journal of Rheumatology; 2294; 2302; 0315-162X; 12; 39; ~The Journal of Rheumatology~2294~2302~~~0315-162X~12~39~~
- Publication Year :
- 2012
-
Abstract
- Contains fulltext : 108354.pdf (publisher's version ) (Closed access)<br />OBJECTIVE: Systemic sclerosis (SSc) is a genetically complex autoimmune disease; the genetic component has not been fully defined. Interleukin 6 (IL-6) plays a crucial role in immunity and fibrosis, both key aspects of SSc. We investigated the influence of IL6 gene in the susceptibility and phenotype expression of SSc. METHODS: We performed a large metaanalysis including a total of 2749 cases and 3189 controls from 6 white populations (Germany, The Netherlands, Norway, Spain, Sweden, and United Kingdom). Three IL6 single-nucleotide polymorphisms (SNP; rs2069827, rs1800795, and rs2069840) were selected by SNP tagging and genotyped using TaqMan((R)) allele discrimination technology. RESULTS: Individual SNP metaanalysis showed no evidence of association of the 3 IL6 genetic variants with the global disease. Phenotype analyses revealed a significant association between the minor allele of rs2069840 and the limited cutaneous SSc clinical form (Bonferroni p = 0.036, OR 1.14, 95% CI 1.04-1.25). A trend of association between the minor allele of the rs1800795 and the diffuse cutaneous SSc clinical form was also evident (Bonferroni p = 0.072, OR 0.86, 95% CI 0.77-0.96). In the IL6 allelic combination analyses, the GGC allelic combination rs2069827-rs1800795-rs2069840 showed an association with overall SSc (Bonferroni p = 0.016, OR 1.13, 95% CI 1.04-1.23). CONCLUSION: Our results suggest that the IL6 gene may influence the development of SSc and its progression.
Details
- Database :
- OAIster
- Journal :
- The Journal of Rheumatology; 2294; 2302; 0315-162X; 12; 39; ~The Journal of Rheumatology~2294~2302~~~0315-162X~12~39~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1366895744
- Document Type :
- Electronic Resource