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Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005-2020), Republic of Karakalpakstan, Uzbekistan

Authors :
Gadoev, J.
Asadov, D.
Harries, A.D.
Kumar, A.M.V.
Boeree, M.J.
Hovhannesyan, A.
Kuppens, L.
Yedilbayev, A.
Korotych, O.
Hamraev, A.
Kudaybergenov, K.
Abdusamatova, B.
Khudanov, B.
Dara, M.
Gadoev, J.
Asadov, D.
Harries, A.D.
Kumar, A.M.V.
Boeree, M.J.
Hovhannesyan, A.
Kuppens, L.
Yedilbayev, A.
Korotych, O.
Hamraev, A.
Kudaybergenov, K.
Abdusamatova, B.
Khudanov, B.
Dara, M.
Source :
International Journal of Environmental Research and Public Health; 1660-4601; 23; 18; 12827; ~International Journal of Environmental Research and Public Health~~~~~1660-4601~23~18~~12827
Publication Year :
2021

Abstract

Contains fulltext : 242604.pdf (Publisher’s version ) (Open Access)<br />Tuberculosis (TB) remains a public health burden in the Republic of Karakalpakstan, Uzbekistan. This region-wide retrospective cohort study reports the treatment outcomes of patients registered in the TB electronic register and treated with first-line drugs in the TB Programme of the Republic of Karakalpakstan from 2005-2020 and factors associated with unfavourable outcomes. Among 35,122 registered patients, 24,394 (69%) patients were adults, 2339 (7%) were children, 18,032 (51%) were male and 19,774 (68%) lived in rural areas. Of these patients, 29,130 (83%) had pulmonary TB and 7497 (>22%) had been previously treated. There were 7440 (21%) patients who had unfavourable treatment outcomes. Factors associated with unfavourable treatment outcomes included: increasing age, living in certain parts of the republic, disability, pensioner status, unemployment, being HIV-positive, having pulmonary TB, and receiving category II treatment. Factors associated with death included: being adult and elderly, living in certain parts of the republic, having a disability, pensioner status, being HIV-positive, and receiving category II treatment. Factors associated with failure included: being adolescent, female, having pulmonary TB. Factors associated with loss to follow-up included: being male, disability, pensioner status, unemployment, receiving category II treatment. In summary, there are sub-groups of patients who need special attention in order to decrease unfavourable treatment outcomes.

Details

Database :
OAIster
Journal :
International Journal of Environmental Research and Public Health; 1660-4601; 23; 18; 12827; ~International Journal of Environmental Research and Public Health~~~~~1660-4601~23~18~~12827
Publication Type :
Electronic Resource
Accession number :
edsoai.on1366864166
Document Type :
Electronic Resource