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Tactile event-related potentials in amyotrophic lateral sclerosis (ALS): Implications for brain-computer interface
- Source :
- Clinical Neurophysiology; 936; 945; 1388-2457; 1; 127; ~Clinical Neurophysiology~936~945~~~1388-2457~1~127~~
- Publication Year :
- 2016
-
Abstract
- Contains fulltext : 150727.pdf (publisher's version ) (Closed access)<br />Objective We investigated neurophysiological brain responses elicited by a tactile event-related potential paradigm in a sample of ALS patients. Underlying cognitive processes and neurophysiological signatures for brain-computer interface (BCI) are addressed. Methods We stimulated the palm of the hand in a group of fourteen ALS patients and a control group of ten healthy participants and recorded electroencephalographic signals in eyes-closed condition. Target and non-target brain responses were analyzed and classified offline. Classification errors served as the basis for neurophysiological brain response sub-grouping. Results A combined behavioral and quantitative neurophysiological analysis of sub-grouped data showed neither significant between-group differences, nor significant correlations between classification performance and the ALS patients’ clinical state. Taking sequential effects of stimuli presentation into account, analyses revealed mean classification errors of 19.4% and 24.3% in healthy participants and ALS patients respectively. Conclusions Neurophysiological correlates of tactile stimuli presentation are not altered by ALS. Tactile event-related potentials can be used to monitor attention level and task performance in ALS and may constitute a viable basis for future BCIs. Significance Implications for brain-computer interface implementation of the proposed method for patients in critical conditions, such as the late stage of ALS and the (completely) locked-in state, are discussed.
Details
- Database :
- OAIster
- Journal :
- Clinical Neurophysiology; 936; 945; 1388-2457; 1; 127; ~Clinical Neurophysiology~936~945~~~1388-2457~1~127~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1366722444
- Document Type :
- Electronic Resource