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Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
Authors :
Habre, Walid Disma, Nicola Virag, Katalin Becke, Karin Hansen, Tom G. Joehr, Martin Leva, Brigitte Morton, Neil S. Vermeulen, Petronella M. Zielinska, Marzena Boda, Krisztina Veyckemans, Francis Klimscha, Walter Konecny, Regina Luntzer, Robert Morawk-Wintersperger, Ulrike Neiger, Franz Rustemeyer, Lydia Breschan, Christian Frey, Denise Platzer, Manuela Germann, Reinhard Oeding, Joachim Stoegermuller, Birgit Ziegler, Bernhard Brotatsch, Philipp Gutmann, Anton Mausser, Gerlinde Messerer, Brigitte Toller, Wolfgang Vittinghoff, Maria Zangl, Gregor Seidel-Ahyai, Natascha Hochhold, Christoph Kroess, Ruth Paal, Peter Cnudde, Steven Coucke, Patricia Loveniers, Birgit Mitchell, John Kahn, David Pirotte, Thierry Pregardien, Caroline Coppens, Marc De Baerdemaeker, Luc De Hert, Stefan Heyse, Bjorn Neckebroek, Martine Parashchanka, Aliaksandra Van Limmen, Jurgen Van Den Eynde, Nancy Vanpeteghem, Caroline Wyffels, Piet Lalot, Michael Lechat, Jean-Paul Stevens, France Casaer, Sari De Groote, Francoise De Pooter, Francoise De Ville, Andree Gerin, Marc Magasich, Natalia Torres, Cristel Sanchez Van Deenen, Denise Berghmans, Johan Himpe, Dirk Roofthooft, Eva Joukes, Ellen Smitz, Carine Van Reeth, Veronique Huygens, Christel Lauweryns, Julie De Smet, Karen Najafi, Nadia Poelaert, Jan Van de Velde, Anne Van Mossevelde, Veerle Bekavac, Ivan Butkovic, Diana Litvic, Dubravka Heli Soric, Ivana Kerovec Maretic, Hrvoje Moscatello, Djurdjica Popovic, Ljiljana Micic, Slobodan Tus, Ivana Stuck Fabris, Lada Kalagac Simurina, Tatjana Sulen, Nina Kesi-Valpotic, Gordana Djapic, Dajana Zurek, Jiri Jureckova, Lucie Mackova, Iveta Skacel, Monika Weinlichova, Stanislava Divak, Jan Frelich, Michal Urbanec, Rene Biskupova, Vera Mixa, Vladimir Pavlickova, Jana Afshari, Arash Bottger, Morten Ellekvist, Marguerite B. Johansen, Mathias Madsen, Birgitte Ingeborg Nilsson, Jens Christian Schousboe, Birgitte M. B. Clausen, Nicola G. Steen, Nick Phaff Ilmoja, Mari-Liis Tonise, Virge Karjagin, Juri Kikas, Reet Isohanni, Mika Lyly, Anniina Takala, Annika Happo, Johanna Kiviluoma, Kai Martikainen, Kati Aantaa, Riku Manner, Tuula Vilo, Sanna Amory, Catherine Ludot, Hugues Lambotte, Patricia Busche, Rene Jacqmarcq, Olivier Lejus, Corinne Corouge, Julien Erb, Christian Garrigue, Delphine Gillet, Patricia Laffargue, Anne Lambelin, Veronique Le Freche, Helene Peresbota, Daliana Richart, Pierre Berton, Jerome Chapotte, Catherine Colbus, Laurent Lehousse, Thierry Monrigal, Jean Baujard, Catherine Roulleau, Philippe Staiti, Giuseppe Batoz, Helene Bordes, Maryline Didier, Anne Hamonic, Yann Lagarde, Sylvaine Nouette-Gaulain, Karine Semjen, Francois Zaghet, Brigitte Dekens, Jacky Delcuze, Axelle Dupont, Herve Legrand, Aurelien Raffoflandreur, Celine Audren, Noemie Camus, Blandine Cartal, Marielle Chazelet, Chantal Davin, Isabelle Guillier, Marion Desjeux, Luc Larcher, Claire Grein, Elodie Leclercq, Mickeal Levitchi, Roxana Rosu, Lilica Simon, Dominique Zang, Aurelien Migeon, Anne Gagey, Anne-Charlotte Bourdaud, Nathalie Carre, Anne-Charlotte Duflo, Frederic Riche, Jean-Claude Robert, Philippe Druot, Emilie Maupain, Olivier Orliaguet, Gilles Sabau, Lucie Taright, Hanna Uhrig, Lynn Verchere-Montmayeur, Juliette Debrabant, Lise Pilla, Clotaire Podvin, Alexandre Roth, Benjamin Dahmani, Souhayl Julien-Marsollier, Florence Sabourdin, Nada Alexandri, Bogdan Brezac, Gilles de la Briere, Francois Hayem, Catherine Lhubat, Elizabeth Mission, Jean Paul Remond, Charlotte Dadure, Christophe Maniora, Maud Marie, Anais Pirat, Philippe Saour, Anne-Charlotte Sola, Chrystelle Ecoffey, Claude Wodey, Eric Adam, Christian Standl, Thomas Schindler, Ehrenfried Yamamoto, Tomohiro Brackhahn, Michael Eich, Christoph Bernhard Guericke, Holger Kindermann, Petra Laschat, Michael Schink, Cornel Wappler, Frank Hoehne, Claudia Skordou, Natalia Ulrici, Johanna Jetzek-Zader, Martin Kienbaum, Peter Meyer-Treschan, Tanja Picker, Olaf Schaefer, Maximilian S. Mielke, Golo Baethge, Sabine Ramminger, Axel Bauer, Martin Bollinger, Matthias Hinz, Jose Quintel, Michael Russo, Sebastian G. Bauer, Michael Geil, Dfominik Kortgen, Andreas Preussler, Niels-Peter Hofmann, Ulrich Raber, Manfred Reindl, Doris Oppenrieder, Karin Schierlinger, Bettina Roth, Jens Funk, Wolfgang Fischer, Thomas Gernoth, Christian Wiefelsputz, Christina Volger, Hauke Zederer, Nicole Diers, Anja Huber, Matthias Schorer, Clemens Weyland, Andreas Schwarzkopf, Konrad Grau, Catharina Roth, Winfried Holy, Rolf Mader, Thomas Peter, Laura Supthut, Hauke Kuehhirt, Thomas Milde, Alexander Fiedler, Fritz Isselhorst, Carsten Grundmann, Ulrich Pattar, Alexander Reinert, Jennifer Ehm, Birgit Fritzsche, Katrin Gaebler, Ralf Meybohm, Patrick Hein, Maximilian Guzman, Ines Jokinen, Johanna Kranke, Peter Goebel, Ulrich Harris, Sarah Eisner, Christoph Ochsenreiter, Miriam Schoeler, Michael Thil, Elke Ellerkmann, Richard Hoeft, Andreas Neumann, Claudia Weber, Stefan Keilhauer, Julia Kloessing, Jan Schramm, Michael Trieschmann, Uwe Knauss, Kristina Sinner, Barbara Steinmann, Johannes Koessler, Herbert Kalliardou, Evagelia Malisiova, Anna Tsiotou, Adelais Chloropoulou, Pelagia Chrysi, Mpratzou Iordanidou, Despoina Ntavlis, Merkourios Rarosi, Ferenc Boda, Krisztina B. Guerin, Christilynn Irwin, Janice Magner, Claire Nakhjavani, Solmaz O'Hare, Brendan Galvin, Deborah Jamil, Yosry Lesmes, Carlos Barak, Yuri Fisher, Haran Kachko, Ludmyla Katz, Jacob Kirilov, Dmitry Levinzon, Michael Manevich, Yair Nekrasov, Konstantin Peled, Elia Sanko, Elena Schmain, Dmitri Sheinkin, Olga Simhi, Eliahu Tarabikin, Alex Trabkin, Evelina Yagudaev, Irena Zeitlin, Yelena Zunser, Igor Habre, Walid Disma, Nicola Virag, Katalin Becke, Karin Hansen, Tom G. Joehr, Martin Leva, Brigitte Morton, Neil S. Vermeulen, Petronella M. Zielinska, Marzena Boda, Krisztina Veyckemans, Francis Klimscha, Walter Konecny, Regina Luntzer, Robert Morawk-Wintersperger, Ulrike Neiger, Franz Rustemeyer, Lydia Breschan, Christian Frey, Denise Platzer, Manuela Germann, Reinhard Oeding, Joachim Stoegermuller, Birgit Ziegler, Bernhard Brotatsch, Philipp Gutmann, Anton Mausser, Gerlinde Messerer, Brigitte Toller, Wolfgang Vittinghoff, Maria Zangl, Gregor Seidel-Ahyai, Natascha Hochhold, Christoph Kroess, Ruth Paal, Peter Cnudde, Steven Coucke, Patricia Loveniers, Birgit Mitchell, John Kahn, David Pirotte, Thierry Pregardien, Caroline Coppens, Marc De Baerdemaeker, Luc De Hert, Stefan Heyse, Bjorn Neckebroek, Martine Parashchanka, Aliaksandra Van Limmen, Jurgen Van Den Eynde, Nancy Vanpeteghem, Caroline Wyffels, Piet Lalot, Michael Lechat, Jean-Paul Stevens, France Casaer, Sari De Groote, Francoise De Pooter, Francoise De Ville, Andree Gerin, Marc Magasich, Natalia Torres, Cristel Sanchez Van Deenen, Denise Berghmans, Johan Himpe, Dirk Roofthooft, Eva Joukes, Ellen Smitz, Carine Van Reeth, Veronique Huygens, Christel Lauweryns, Julie De Smet, Karen Najafi, Nadia Poelaert, Jan Van de Velde, Anne Van Mossevelde, Veerle Bekavac, Ivan Butkovic, Diana Litvic, Dubravka Heli Soric, Ivana Kerovec Maretic, Hrvoje Moscatello, Djurdjica Popovic, Ljiljana Micic, Slobodan Tus, Ivana Stuck Fabris, Lada Kalagac Simurina, Tatjana Sulen, Nina Kesi-Valpotic, Gordana Djapic, Dajana Zurek, Jiri Jureckova, Lucie Mackova, Iveta Skacel, Monika Weinlichova, Stanislava Divak, Jan Frelich, Michal Urbanec, Rene Biskupova, Vera Mixa, Vladimir Pavlickova, Jana Afshari, Arash Bottger, Morten Ellekvist, Marguerite B. Johansen, Mathias Madsen, Birgitte Ingeborg Nilsson, Jens Christian Schousboe, Birgitte M. B. Clausen, Nicola G. Steen, Nick Phaff Ilmoja, Mari-Liis Tonise, Virge Karjagin, Juri Kikas, Reet Isohanni, Mika Lyly, Anniina Takala, Annika Happo, Johanna Kiviluoma, Kai Martikainen, Kati Aantaa, Riku Manner, Tuula Vilo, Sanna Amory, Catherine Ludot, Hugues Lambotte, Patricia Busche, Rene Jacqmarcq, Olivier Lejus, Corinne Corouge, Julien Erb, Christian Garrigue, Delphine Gillet, Patricia Laffargue, Anne Lambelin, Veronique Le Freche, Helene Peresbota, Daliana Richart, Pierre Berton, Jerome Chapotte, Catherine Colbus, Laurent Lehousse, Thierry Monrigal, Jean Baujard, Catherine Roulleau, Philippe Staiti, Giuseppe Batoz, Helene Bordes, Maryline Didier, Anne Hamonic, Yann Lagarde, Sylvaine Nouette-Gaulain, Karine Semjen, Francois Zaghet, Brigitte Dekens, Jacky Delcuze, Axelle Dupont, Herve Legrand, Aurelien Raffoflandreur, Celine Audren, Noemie Camus, Blandine Cartal, Marielle Chazelet, Chantal Davin, Isabelle Guillier, Marion Desjeux, Luc Larcher, Claire Grein, Elodie Leclercq, Mickeal Levitchi, Roxana Rosu, Lilica Simon, Dominique Zang, Aurelien Migeon, Anne Gagey, Anne-Charlotte Bourdaud, Nathalie Carre, Anne-Charlotte Duflo, Frederic Riche, Jean-Claude Robert, Philippe Druot, Emilie Maupain, Olivier Orliaguet, Gilles Sabau, Lucie Taright, Hanna Uhrig, Lynn Verchere-Montmayeur, Juliette Debrabant, Lise Pilla, Clotaire Podvin, Alexandre Roth, Benjamin Dahmani, Souhayl Julien-Marsollier, Florence Sabourdin, Nada Alexandri, Bogdan Brezac, Gilles de la Briere, Francois Hayem, Catherine Lhubat, Elizabeth Mission, Jean Paul Remond, Charlotte Dadure, Christophe Maniora, Maud Marie, Anais Pirat, Philippe Saour, Anne-Charlotte Sola, Chrystelle Ecoffey, Claude Wodey, Eric Adam, Christian Standl, Thomas Schindler, Ehrenfried Yamamoto, Tomohiro Brackhahn, Michael Eich, Christoph Bernhard Guericke, Holger Kindermann, Petra Laschat, Michael Schink, Cornel Wappler, Frank Hoehne, Claudia Skordou, Natalia Ulrici, Johanna Jetzek-Zader, Martin Kienbaum, Peter Meyer-Treschan, Tanja Picker, Olaf Schaefer, Maximilian S. Mielke, Golo Baethge, Sabine Ramminger, Axel Bauer, Martin Bollinger, Matthias Hinz, Jose Quintel, Michael Russo, Sebastian G. Bauer, Michael Geil, Dfominik Kortgen, Andreas Preussler, Niels-Peter Hofmann, Ulrich Raber, Manfred Reindl, Doris Oppenrieder, Karin Schierlinger, Bettina Roth, Jens Funk, Wolfgang Fischer, Thomas Gernoth, Christian Wiefelsputz, Christina Volger, Hauke Zederer, Nicole Diers, Anja Huber, Matthias Schorer, Clemens Weyland, Andreas Schwarzkopf, Konrad Grau, Catharina Roth, Winfried Holy, Rolf Mader, Thomas Peter, Laura Supthut, Hauke Kuehhirt, Thomas Milde, Alexander Fiedler, Fritz Isselhorst, Carsten Grundmann, Ulrich Pattar, Alexander Reinert, Jennifer Ehm, Birgit Fritzsche, Katrin Gaebler, Ralf Meybohm, Patrick Hein, Maximilian Guzman, Ines Jokinen, Johanna Kranke, Peter Goebel, Ulrich Harris, Sarah Eisner, Christoph Ochsenreiter, Miriam Schoeler, Michael Thil, Elke Ellerkmann, Richard Hoeft, Andreas Neumann, Claudia Weber, Stefan Keilhauer, Julia Kloessing, Jan Schramm, Michael Trieschmann, Uwe Knauss, Kristina Sinner, Barbara Steinmann, Johannes Koessler, Herbert Kalliardou, Evagelia Malisiova, Anna Tsiotou, Adelais Chloropoulou, Pelagia Chrysi, Mpratzou Iordanidou, Despoina Ntavlis, Merkourios Rarosi, Ferenc Boda, Krisztina B. Guerin, Christilynn Irwin, Janice Magner, Claire Nakhjavani, Solmaz O'Hare, Brendan Galvin, Deborah Jamil, Yosry Lesmes, Carlos Barak, Yuri Fisher, Haran Kachko, Ludmyla Katz, Jacob Kirilov, Dmitry Levinzon, Michael Manevich, Yair Nekrasov, Konstantin Peled, Elia Sanko, Elena Schmain, Dmitri Sheinkin, Olga Simhi, Eliahu Tarabikin, Alex Trabkin, Evelina Yagudaev, Irena Zeitlin, Yelena Zunser, Igor
Publication Year :
2017
Abstract
Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1364918364
Document Type :
Electronic Resource