Antiproliferative activity of 2,3-disubstituted indoles toward apoptosis-resistant cancers cells.

Authors :: Magedov, Igor V
Lefranc, Florence
Frolova, Liliya V
Banuls, Laetitia Moreno Y
Peretti, Amanda S
Rogelj, Snezna
Mathieu, Véronique
Kiss, Robert
Kornienko, Alexander
Magedov, Igor V
Lefranc, Florence
Frolova, Liliya V
Banuls, Laetitia Moreno Y
Peretti, Amanda S
Rogelj, Snezna
Mathieu, Véronique
Kiss, Robert
Kornienko, Alexander
Source :: Bioorganic & medicinal chemistry letters, 23 (11
Publication Year :: 2013
Abstract: Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostatic rather than cytotoxic effects in cancer cells, and serve as a new chemical scaffold to develop anticancer agents capable of combating apoptosis-resistant cancers associated with dismal prognoses.<br />Journal Article<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published

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