Synthesis, characterization, X-ray crystal structure and in vitro antitumour activity of bis(1,2-dicarba-closododecaborane-9-carboxylato)di-n-butyltin

Authors :: Bregadze, V I
Glazun, S A
Petrovskii, P.V.
Starikova, Eugeniya
Rochev, V.Ya.
Dalil, Hassan
Biesemans, Monique
Willem, Rudolph
Gielen, Marcel
De Vos, Danièle
Bregadze, V I
Glazun, S A
Petrovskii, P.V.
Starikova, Eugeniya
Rochev, V.Ya.
Dalil, Hassan
Biesemans, Monique
Willem, Rudolph
Gielen, Marcel
De Vos, Danièle
Source :: Applied organometallic chemistry, 17 (6-7
Publication Year :: 2003
Abstract: The 1 :2 condensation of dibutyltin(IV) oxide with 1,2-carborane-9-carboxylic acid resulted in bis(1,2-dicarba-closo-dodecaborane-9-carboxylato)di-n-butyltin (1), the first carborane-based organotin compound where the carborane cage is linked to the carboxylic moiety via a boron atom. The structure of 1, characterized by 1H, 11B, 13C, 119Sn NMR spectroscopy and X-ray diffraction, was shown to correspond to bis(1,2-dicarba-closo-dodecaborane-9-carboxylato)di-n-butyltin. Compound 1 was screened in vitro against seven tumour cell lines of human origin and was found to be significantly more active than 5-fluorouracil, cis-platin and carboplatin but less active than methotrexate and doxorubicin. Copyright © 2003 John Wiley & Sons, Ltd.<br />Special Issue: Dedicated to Professor Thomas P. Fehlner on the occasion of his 65th birthday<br />FLWIN<br />info:eu-repo/semantics/published

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