Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in remission.

Krabbendam l, honig a, wiersma j, vuurman efpm, hofman pam, derix mma, nolen wa, jolles j. Cognitive dysfunctions and white matter lesions in patients with bipolar disorder in remission. Acta psychiatr scand 2000: 101: 274–280. Objective: to compare cognitive functioning in relation to white matter lesions in bipolar disorder in remission and schizophrenia. Method: cognitive performance and the occurrence of white matter lesions on mri images of the brain were assessed in 22 patients with bipolar disorder in remission, 22 patients with schizophrenia and 22 healthy volunteers. Results: performance of tests of memory, speed and cognitive flexibility was significantly impaired in both patient groups. The frequency of white matter lesions did not differ significantly between the three groups. No differences in cognitive performance were found between patients with white matter lesions and patients without such lesions. Conclusion: white matter lesions apparently do not underlie cognitive deficits that are found in patients with bipolar disorder in remission and in patients with schizophrenia.