Tetravalent Metal Ion Guests in Polyoxopalladate Chemistry: Synthesis and Anticancer Activity of [MO8Pd12(PO4)8]12-(M=SnIV, PbIV)

Authors :: Yang, Peng
Ma, Tian
Lang, Zhongling
Misirlić-Denčić, Sonja
Isaković, Anđelka
Benyei, Attila
Čolović, Mirjana B.
Marković, Ivanka
Krstić, Danijela Z.
Poblet, Josep M.
Lin, Zhengguo
Kortz, Ulrich
Yang, Peng
Ma, Tian
Lang, Zhongling
Misirlić-Denčić, Sonja
Isaković, Anđelka
Benyei, Attila
Čolović, Mirjana B.
Marković, Ivanka
Krstić, Danijela Z.
Poblet, Josep M.
Lin, Zhengguo
Kortz, Ulrich
Source :: Inorganic Chemistry
Publication Year :: 2019
Abstract: The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.

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