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Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score
Authors :
Carbone, M Nardi, A Flack, S Carpino, G Varvaropoulou, N Gavrila, C Spicer, A Badrock, J Bernuzzi, F Cardinale, V Ainsworth, H Heneghan, M Thorburn, D Bathgate, A Jones, R Neuberger, J Battezzati, P Zuin, M Taylor-Robinson, S Donato, M Kirby, J Mitchell-Thain, R Floreani, A Sampaziotis, F Muratori, L Alvaro, D Marzioni, M Miele, L Marra, F Giannini, E Gaudio, E Ronca, V Bonato, G Cristoferi, L Malinverno, F Gerussi, A Stocken, D Cordell, H Hirschfield, G Alexander, G Sandford, R Jones, D Invernizzi, P Mells, G Thomas, C Rahman, M Yapp, T Lye Ch'ng, C Harrison, M Sturgess, R Galaska, R Healey, C Whiteman, J Czaijkowski, M Gray, C Gunasekera, A Gyawli, P Premchand, P Mann, S Elliott, K Kapur, K Watson, A Foster, G Trembling, P Subhani, J Harvey, R Mccorry, R Adgey, C Hobson, L Mulvaney-Jones, C Evans, R Mathialahan, T Ramanaden, D Gasem, J Van Duyvenvoorde, G Shorrock, C Seward, K Southern, P Tibble, J Penn, R Gorard, D Maiden, J Damant, R Palegwala, A Jones, S Dolwani, S Prince, M Silvestre, V Foxton, M Dungca, E Mitchison, H Wheatley, N Gooding, I Doyle, H Karmo, M Kent, M Saksena, S Braim, D Patel, M Lord, S Ede, R Paton, A Austin, A Lancaster, N Sayer, J Gibbins, A Hogben, K Hovell, C Fisher, N Carter, M Koss, K Musselwhite, J Muscariu, F Piotreowicz, A Mckay, A Grimley, C Neal, D Ting Tan, L Lim, G Brighton, J Foale, C Ala, A Saeed, A Flahive, K Wood, G Townshend, P Ford, C Brown, J Kordula, J Bowles, J Wilkinson, M Palmer, C Ramage, J Gordon, H Featherstone, J Ridpath, J Ngatchu, T Levi, S Shaukat, S Sadeghian, J Shidrawi, R Williams, B Abouda, G Duggan, C Hynes, A Narain, M Rees, I Salam, I Crossey, M Brown, A Macnicol, C Williams, S Wilhelmsen, E Banim, P Raymode, P Chilton, A Das, D Lee, H Curtis, H Gess, M Durant, E Drake, I Bishop, R Davies, M Aldersley, M Ncube, N Mcnair, A Srirajaskanthan, R Sen, S Casey, R Bird, G Mendall, M Cowley, C Barnardo, A Kitchen, P Yoong, K Amore, K Sirdefield, D Orpe, J Mathew, R Macfaul, G Wrigth, A Shah, A Evans, C Keggans, J Bird, B Baxter, G Saha, S Pollock, K Hughes, M Bramley, P Grieve, E Young, K Fraser, A Mukhopadhya, A Ocker, K Mills, P Hines, F Shallcross, C Wilkins, J Grellier, L Campbell, S Martin, K Innes, C Shepherd, A Rushbrook, S Valliani, T Przemioslo, R Fairlamb, H Macdonald, C Eastick, A Metcalf, J Tanqueray, E Shmueli, U Holbrook, B Davis, A Browning, J Naqvi, A Walker, K Lee, T Verheyden, J Slininger, S Ryder, S Chapman, R Collier, J O'Donnell, D Stafford, L Williamson, K Kent, L Klass, H Ninkovic, M March, L Cramp, M Simpson, D Dickson, C Sharer, N Hayes, M Goggin, P Quinne, M Pearson, S Hoeroldt, B Jones, L Wright, A Booth, J Loftus, A Lipscomb, G Dewhurst, H Gunter, E Williams, E Fouracres, A Farrington, L Graves, L Hussaini, H Stableforth, B Marriott, S Ayres, R Leoni, M Burroughs, A Marshall, E Tyrer, D Lombard, M Patanwala, I Dali-Kemmery, L Lambourne, V Maltby, J Vyas, S Colley, J Shinder, B Singhal, S Jones, J Mills, M Gleeson, D Carnahan, M Butterworth, J Boulton, K Taylor, N George, K Harding, T Tregonning, J Douglass, A Brown, C Clifford, G Panter, S Gocher, D Shearman, J Bray, G Hamilton, M Butcher, G Forton, D Mclindon, J Curtis, J Shewan, T Cowan, M Whatley, G Nasseri, M Grover, B Sivaramakrishnan, N Ducker, S Houghton, K Griffiths, L Tripoli, S Pitcher, M Shpuza, E White, N Ghosh, D Douds, A Green, M Brookes, M Cumlat, L Wong, V Warner, K Netherton, K Mandal, A Jain, S Gupta, H Sanghi, P Pereira, S Gunson, B Lim, R Gallagher, S Clement, D Brind, A Watts, G Mupudzi, M Wright, M Gitahi, J Gordon, F Unitt, E Pateman, H Batham, S Delahooke, T Grant, A Conder, J Higham, A Cox, M O'Donohoe, L Currie, L King, A Oblak, M Collins, C Whalley, S Quinn, M Baird, Y Amey, I Fraser, J Li, A Cotterill, D Bell, A Singhal, A Gee, I Greer, S Ang, Y Ransford, R Allison, J Gotto, J Dyer, S Sweeting, H Millson, C Labbadia, G Bragazzi, M Andreone, P Azzaroli, F Galli, A Tarocchi, M Gasbarrini, A Grieco, A Marrone, G Valenti, L Maroni, L Rigamonti, C Picciotto, A Carbone, Marco Nardi, Alessandra Flack, Steve Carpino, Guido Varvaropoulou, Nikoletta Gavrila, Caius Spicer, Ann Badrock, Jonathan Bernuzzi, Francesca Cardinale, Vincenzo Ainsworth, Holly F Heneghan, Michael A Thorburn, Douglas Bathgate, Andrew Jones, Rebecca Neuberger, James M Battezzati, Pier Maria Zuin, Massimo Taylor-Robinson, Simon Donato, Maria F Kirby, John Mitchell-Thain, Robert Floreani, Annarosa Sampaziotis, Fotios Muratori, Luigi Alvaro, Domenico Marzioni, Marco Miele, Luca Marra, Fabio Giannini, Edoardo Gaudio, Eugenio Ronca, Vincenzo Bonato, Giulia Cristoferi, Laura Malinverno, Federica Gerussi, Alessio Stocken, Deborah D Cordell, Heather J Hirschfield, Gideon M Alexander, Graeme J Sandford, Richard N Jones, David E Invernizzi, Pietro Mells, George F Thomas, Caradog Rahman, Meshbah Yapp, Tom Lye Ch'ng, Chin Harrison, Melanie Sturgess, Richard Galaska, Roman Healey, Chris Whiteman, Jessica Czaijkowski, Marek Gray, Catherine Gunasekera, Anton Gyawli, Pranab Premchand, Purushothaman Mann, Steven Elliott, Keith Kapur, Kapil Watson, Alan Foster, Graham Trembling, Paul Subhani, Javaid Harvey, Rory McCorry, Roger Adgey, Carolyn Hobson, Lucie Mulvaney-Jones, Caroline Evans, Richard Mathialahan, Thiriloganathan Ramanaden, David Gasem, Jaber Van Duyvenvoorde, Greta Shorrock, Christopher Seward, Katie Southern, Paul Tibble, Jeremy Penn, Ruth Gorard, David Maiden, Jane Damant, Rose Palegwala, Altaf Jones, Susan Alexander, Graeme Mells, George Sandford, Richard Dolwani, Sunil Prince, Martin Silvestre, Valeria Foxton, Matthew Dungca, Eleanor Mitchison, Harriet Wheatley, Natalie Gooding, Ian Doyle, Helen Karmo, Mazn Kent, Melanie Saksena, Sushma Braim, Delyth Patel, Minesh Lord, Susan Ede, Roland Paton, Alison Austin, Andrew Lancaster, Nicola Sayer, Joanna Gibbins, Andrew Hogben, Karen Hovell, Chris Fisher, Neil Carter, Martyn Koss, Konrad Musselwhite, Janine Muscariu, Florin Piotreowicz, Andrzej McKay, Alexandra Grimley, Charles Neal, David Ting Tan, Lai Lim, Guan Brighton, Jacqueline Foale, Carole Ala, Aftab Saeed, Athar Flahive, Kerry Wood, Gordon Townshend, Paula Ford, Chris Brown, Jonathan Kordula, Jean Bowles, Jane Wilkinson, Mark Palmer, Caroline Ramage, John Gordon, Harriet Featherstone, James Ridpath, Jo Ngatchu, Theodore Levi, Sass Shaukat, Syed Sadeghian, Joy Shidrawi, Ray Williams, Bronwen Abouda, George Jones, Sarah Duggan, Claire Hynes, Abigail Narain, Mark Rees, Ian Salam, Imroz Crossey, Mary Brown, Ashley MacNicol, Carolyn Williams, Simon Wilhelmsen, Elva Banim, Paul Raymode, Parizade Chilton, Andrew Das, Debasish Lee, Hye-Jeong Curtis, Howard Heneghan, Michael Gess, Markus Durant, Emma Drake, I. M. Bishop, Rebecca Davies, Mervyn Aldersley, Mark Ncube, Noma McNair, Alistair Srirajaskanthan, Raj Sen, Sambit Casey, Rebecca Bird, George Mendall, Mike Cowley, Caroline Barnardo, Adrian Kitchen, Paul Yoong, Kevin Amore, Kelly Sirdefield, Dawn Orpe, Jacky Mathew, Ray MacFaul, George Wrigth, Aruna Shah, Amir Evans, Chris Keggans, Janie Bird, Bridget Baxter, Gwen Saha, Subrata Pollock, Katharine Hughes, Maggie Bramley, Peter Grieve, Emma Young, Karin Fraser, Andrew Mukhopadhya, Ashis Ocker, Kate Mills, Peter Hines, Francis Shallcross, Chris Wilkins, Joy Grellier, Leonie Campbell, Stewart Martin, Kirsty Innes, Caron Shepherd, Alan Rushbrook, Simon Valliani, Talal Przemioslo, Robert Fairlamb, Helen Macdonald, Chris Eastick, Anne Metcalf, Jane Tanqueray, Elizabeth Shmueli, Udi Holbrook, Becky Davis, Andrew Browning, Julie Naqvi, Asifabbas Walker, Kirsten Lee, Tom Verheyden, Juliette Slininger, Susan Ryder, Stephen D Chapman, Roger Collier, Jane O'Donnell, Denise Stafford, Lizzie Williamson, Kate Kent, Linda Klass, Howard Ninkovic, Mary March, Linda Cramp, Matthew Simpson, Diane Dickson, Christine Sharer, Nicholas Hayes, Maria Goggin, Patrick Quinne, Mary Pearson, Sallyanne Hoeroldt, Barbara Jones, Linda Wright, Alice Booth, Jonathan Loftus, Alison Lipscomb, George Dewhurst, Hannah Gunter, Emma Williams, Earl Fouracres, Anna Farrington, Liz Graves, Lyn Hussaini, Hyder Stableforth, Bill Marriott, Suzie Ayres, Reuben Leoni, Marina Burroughs, Andrew Marshall, Eileen Tyrer, David Martin, Kate Lombard, Martin Patanwala, Imran Dali-Kemmery, Lola Lambourne, Victoria Maltby, Julia Vyas, Samir Colley, Julie Shinder, Bal Singhal, Saket Jones, Jayne Mills, Marisa Gleeson, Dermot Carnahan, Mandy Butterworth, Jeff Boulton, Kerenza Taylor, Natalie George, Keith Harding, Tim Tregonning, Julie Douglass, Andrew Brown, Carly Clifford, Gayle Panter, Simon Gocher, Denise Shearman, Jeremy Bray, Gary Hamilton, Maria Butcher, Graham Forton, Daniel Mclindon, John Curtis, Janette Das, Debashis Shewan, Tracey Cowan, Matthew Whatley, Gregory Nasseri, Mariam Grover, Bob Sivaramakrishnan, Nurani Ducker, Samantha Houghton, Kathryn Jones, David Griffiths, Laura Tripoli, Sherill Pitcher, Maxton Shpuza, Ervin White, Nikki Ghosh, Deb Douds, Andrew Green, Marie Brookes, Matthew Cumlat, Lourdes Wong, Voi Shim Warner, Karen Netherton, Kimberley Mandal, Adtya Jain, Snjiv Gupta, Hemant Sanghi, Pradeep Pereira, Steve Neuberger, James Gunson, Bridget Hirschfield, Gideon Lim, Reina Teegan Gallagher, Susan Clement, Darren Brind, Alison Watts, Gill Mupudzi, Mcdonald Wright, Mark Gitahi, Jane Gordon, Fiona Gocher, Denis Unitt, Esther Pateman, Hilary Batham, Sally Delahooke, Toby Grant, Allister Conder, Jill Higham, Andrew Cox, Mark O'Donohoe, Lynn Currie, Lynn King, Alistair Oblak, Metod Collins, Carole Whalley, Simon Quinn, Marie Baird, Yolanda Amey, Isobel Fraser, Jocelyn Li, Andy Cotterill, Donna Bell, Andrew Singhal, Amit Gee, Ian Greer, Sandra Ang, Yeng Ransford, Rupert Allison, Joanna Gotto, James Dyer, Simon Sweeting, Helen Millson, Charles Labbadia, Giancarlo Bragazzi, Maria Consiglia Andreone, Pietro Azzaroli, Francesco Galli, Andrea Tarocchi, Mirko Gasbarrini, Antonio GRIECO, ANTONIO Marrone, Giuseppe Donato, Maria Francesca Valenti, Luca Maroni, Luca Rigamonti, Cristina Picciotto, Antonino Carbone, M Nardi, A Flack, S Carpino, G Varvaropoulou, N Gavrila, C Spicer, A Badrock, J Bernuzzi, F Cardinale, V Ainsworth, H Heneghan, M Thorburn, D Bathgate, A Jones, R Neuberger, J Battezzati, P Zuin, M Taylor-Robinson, S Donato, M Kirby, J Mitchell-Thain, R Floreani, A Sampaziotis, F Muratori, L Alvaro, D Marzioni, M Miele, L Marra, F Giannini, E Gaudio, E Ronca, V Bonato, G Cristoferi, L Malinverno, F Gerussi, A Stocken, D Cordell, H Hirschfield, G Alexander, G Sandford, R Jones, D Invernizzi, P Mells, G Thomas, C Rahman, M Yapp, T Lye Ch'ng, C Harrison, M Sturgess, R Galaska, R Healey, C Whiteman, J Czaijkowski, M Gray, C Gunasekera, A Gyawli, P Premchand, P Mann, S Elliott, K Kapur, K Watson, A Foster, G Trembling, P Subhani, J Harvey, R Mccorry, R Adgey, C Hobson, L Mulvaney-Jones, C Evans, R Mathialahan, T Ramanaden, D Gasem, J Van Duyvenvoorde, G Shorrock, C Seward, K Southern, P Tibble, J Penn, R Gorard, D Maiden, J Damant, R Palegwala, A Jones, S Dolwani, S Prince, M Silvestre, V Foxton, M Dungca, E Mitchison, H Wheatley, N Gooding, I Doyle, H Karmo, M Kent, M Saksena, S Braim, D Patel, M Lord, S Ede, R Paton, A Austin, A Lancaster, N Sayer, J Gibbins, A Hogben, K Hovell, C Fisher, N Carter, M Koss, K Musselwhite, J Muscariu, F Piotreowicz, A Mckay, A Grimley, C Neal, D Ting Tan, L Lim, G Brighton, J Foale, C Ala, A Saeed, A Flahive, K Wood, G Townshend, P Ford, C Brown, J Kordula, J Bowles, J Wilkinson, M Palmer, C Ramage, J Gordon, H Featherstone, J Ridpath, J Ngatchu, T Levi, S Shaukat, S Sadeghian, J Shidrawi, R Williams, B Abouda, G Duggan, C Hynes, A Narain, M Rees, I Salam, I Crossey, M Brown, A Macnicol, C Williams, S Wilhelmsen, E Banim, P Raymode, P Chilton, A Das, D Lee, H Curtis, H Gess, M Durant, E Drake, I Bishop, R Davies, M Aldersley, M Ncube, N Mcnair, A Srirajaskanthan, R Sen, S Casey, R Bird, G Mendall, M Cowley, C Barnardo, A Kitchen, P Yoong, K Amore, K Sirdefield, D Orpe, J Mathew, R Macfaul, G Wrigth, A Shah, A Evans, C Keggans, J Bird, B Baxter, G Saha, S Pollock, K Hughes, M Bramley, P Grieve, E Young, K Fraser, A Mukhopadhya, A Ocker, K Mills, P Hines, F Shallcross, C Wilkins, J Grellier, L Campbell, S Martin, K Innes, C Shepherd, A Rushbrook, S Valliani, T Przemioslo, R Fairlamb, H Macdonald, C Eastick, A Metcalf, J Tanqueray, E Shmueli, U Holbrook, B Davis, A Browning, J Naqvi, A Walker, K Lee, T Verheyden, J Slininger, S Ryder, S Chapman, R Collier, J O'Donnell, D Stafford, L Williamson, K Kent, L Klass, H Ninkovic, M March, L Cramp, M Simpson, D Dickson, C Sharer, N Hayes, M Goggin, P Quinne, M Pearson, S Hoeroldt, B Jones, L Wright, A Booth, J Loftus, A Lipscomb, G Dewhurst, H Gunter, E Williams, E Fouracres, A Farrington, L Graves, L Hussaini, H Stableforth, B Marriott, S Ayres, R Leoni, M Burroughs, A Marshall, E Tyrer, D Lombard, M Patanwala, I Dali-Kemmery, L Lambourne, V Maltby, J Vyas, S Colley, J Shinder, B Singhal, S Jones, J Mills, M Gleeson, D Carnahan, M Butterworth, J Boulton, K Taylor, N George, K Harding, T Tregonning, J Douglass, A Brown, C Clifford, G Panter, S Gocher, D Shearman, J Bray, G Hamilton, M Butcher, G Forton, D Mclindon, J Curtis, J Shewan, T Cowan, M Whatley, G Nasseri, M Grover, B Sivaramakrishnan, N Ducker, S Houghton, K Griffiths, L Tripoli, S Pitcher, M Shpuza, E White, N Ghosh, D Douds, A Green, M Brookes, M Cumlat, L Wong, V Warner, K Netherton, K Mandal, A Jain, S Gupta, H Sanghi, P Pereira, S Gunson, B Lim, R Gallagher, S Clement, D Brind, A Watts, G Mupudzi, M Wright, M Gitahi, J Gordon, F Unitt, E Pateman, H Batham, S Delahooke, T Grant, A Conder, J Higham, A Cox, M O'Donohoe, L Currie, L King, A Oblak, M Collins, C Whalley, S Quinn, M Baird, Y Amey, I Fraser, J Li, A Cotterill, D Bell, A Singhal, A Gee, I Greer, S Ang, Y Ransford, R Allison, J Gotto, J Dyer, S Sweeting, H Millson, C Labbadia, G Bragazzi, M Andreone, P Azzaroli, F Galli, A Tarocchi, M Gasbarrini, A Grieco, A Marrone, G Valenti, L Maroni, L Rigamonti, C Picciotto, A Carbone, Marco Nardi, Alessandra Flack, Steve Carpino, Guido Varvaropoulou, Nikoletta Gavrila, Caius Spicer, Ann Badrock, Jonathan Bernuzzi, Francesca Cardinale, Vincenzo Ainsworth, Holly F Heneghan, Michael A Thorburn, Douglas Bathgate, Andrew Jones, Rebecca Neuberger, James M Battezzati, Pier Maria Zuin, Massimo Taylor-Robinson, Simon Donato, Maria F Kirby, John Mitchell-Thain, Robert Floreani, Annarosa Sampaziotis, Fotios Muratori, Luigi Alvaro, Domenico Marzioni, Marco Miele, Luca Marra, Fabio Giannini, Edoardo Gaudio, Eugenio Ronca, Vincenzo Bonato, Giulia Cristoferi, Laura Malinverno, Federica Gerussi, Alessio Stocken, Deborah D Cordell, Heather J Hirschfield, Gideon M Alexander, Graeme J Sandford, Richard N Jones, David E Invernizzi, Pietro Mells, George F Thomas, Caradog Rahman, Meshbah Yapp, Tom Lye Ch'ng, Chin Harrison, Melanie Sturgess, Richard Galaska, Roman Healey, Chris Whiteman, Jessica Czaijkowski, Marek Gray, Catherine Gunasekera, Anton Gyawli, Pranab Premchand, Purushothaman Mann, Steven Elliott, Keith Kapur, Kapil Watson, Alan Foster, Graham Trembling, Paul Subhani, Javaid Harvey, Rory McCorry, Roger Adgey, Carolyn Hobson, Lucie Mulvaney-Jones, Caroline Evans, Richard Mathialahan, Thiriloganathan Ramanaden, David Gasem, Jaber Van Duyvenvoorde, Greta Shorrock, Christopher Seward, Katie Southern, Paul Tibble, Jeremy Penn, Ruth Gorard, David Maiden, Jane Damant, Rose Palegwala, Altaf Jones, Susan Alexander, Graeme Mells, George Sandford, Richard Dolwani, Sunil Prince, Martin Silvestre, Valeria Foxton, Matthew Dungca, Eleanor Mitchison, Harriet Wheatley, Natalie Gooding, Ian Doyle, Helen Karmo, Mazn Kent, Melanie Saksena, Sushma Braim, Delyth Patel, Minesh Lord, Susan Ede, Roland Paton, Alison Austin, Andrew Lancaster, Nicola Sayer, Joanna Gibbins, Andrew Hogben, Karen Hovell, Chris Fisher, Neil Carter, Martyn Koss, Konrad Musselwhite, Janine Muscariu, Florin Piotreowicz, Andrzej McKay, Alexandra Grimley, Charles Neal, David Ting Tan, Lai Lim, Guan Brighton, Jacqueline Foale, Carole Ala, Aftab Saeed, Athar Flahive, Kerry Wood, Gordon Townshend, Paula Ford, Chris Brown, Jonathan Kordula, Jean Bowles, Jane Wilkinson, Mark Palmer, Caroline Ramage, John Gordon, Harriet Featherstone, James Ridpath, Jo Ngatchu, Theodore Levi, Sass Shaukat, Syed Sadeghian, Joy Shidrawi, Ray Williams, Bronwen Abouda, George Jones, Sarah Duggan, Claire Hynes, Abigail Narain, Mark Rees, Ian Salam, Imroz Crossey, Mary Brown, Ashley MacNicol, Carolyn Williams, Simon Wilhelmsen, Elva Banim, Paul Raymode, Parizade Chilton, Andrew Das, Debasish Lee, Hye-Jeong Curtis, Howard Heneghan, Michael Gess, Markus Durant, Emma Drake, I. M. Bishop, Rebecca Davies, Mervyn Aldersley, Mark Ncube, Noma McNair, Alistair Srirajaskanthan, Raj Sen, Sambit Casey, Rebecca Bird, George Mendall, Mike Cowley, Caroline Barnardo, Adrian Kitchen, Paul Yoong, Kevin Amore, Kelly Sirdefield, Dawn Orpe, Jacky Mathew, Ray MacFaul, George Wrigth, Aruna Shah, Amir Evans, Chris Keggans, Janie Bird, Bridget Baxter, Gwen Saha, Subrata Pollock, Katharine Hughes, Maggie Bramley, Peter Grieve, Emma Young, Karin Fraser, Andrew Mukhopadhya, Ashis Ocker, Kate Mills, Peter Hines, Francis Shallcross, Chris Wilkins, Joy Grellier, Leonie Campbell, Stewart Martin, Kirsty Innes, Caron Shepherd, Alan Rushbrook, Simon Valliani, Talal Przemioslo, Robert Fairlamb, Helen Macdonald, Chris Eastick, Anne Metcalf, Jane Tanqueray, Elizabeth Shmueli, Udi Holbrook, Becky Davis, Andrew Browning, Julie Naqvi, Asifabbas Walker, Kirsten Lee, Tom Verheyden, Juliette Slininger, Susan Ryder, Stephen D Chapman, Roger Collier, Jane O'Donnell, Denise Stafford, Lizzie Williamson, Kate Kent, Linda Klass, Howard Ninkovic, Mary March, Linda Cramp, Matthew Simpson, Diane Dickson, Christine Sharer, Nicholas Hayes, Maria Goggin, Patrick Quinne, Mary Pearson, Sallyanne Hoeroldt, Barbara Jones, Linda Wright, Alice Booth, Jonathan Loftus, Alison Lipscomb, George Dewhurst, Hannah Gunter, Emma Williams, Earl Fouracres, Anna Farrington, Liz Graves, Lyn Hussaini, Hyder Stableforth, Bill Marriott, Suzie Ayres, Reuben Leoni, Marina Burroughs, Andrew Marshall, Eileen Tyrer, David Martin, Kate Lombard, Martin Patanwala, Imran Dali-Kemmery, Lola Lambourne, Victoria Maltby, Julia Vyas, Samir Colley, Julie Shinder, Bal Singhal, Saket Jones, Jayne Mills, Marisa Gleeson, Dermot Carnahan, Mandy Butterworth, Jeff Boulton, Kerenza Taylor, Natalie George, Keith Harding, Tim Tregonning, Julie Douglass, Andrew Brown, Carly Clifford, Gayle Panter, Simon Gocher, Denise Shearman, Jeremy Bray, Gary Hamilton, Maria Butcher, Graham Forton, Daniel Mclindon, John Curtis, Janette Das, Debashis Shewan, Tracey Cowan, Matthew Whatley, Gregory Nasseri, Mariam Grover, Bob Sivaramakrishnan, Nurani Ducker, Samantha Houghton, Kathryn Jones, David Griffiths, Laura Tripoli, Sherill Pitcher, Maxton Shpuza, Ervin White, Nikki Ghosh, Deb Douds, Andrew Green, Marie Brookes, Matthew Cumlat, Lourdes Wong, Voi Shim Warner, Karen Netherton, Kimberley Mandal, Adtya Jain, Snjiv Gupta, Hemant Sanghi, Pradeep Pereira, Steve Neuberger, James Gunson, Bridget Hirschfield, Gideon Lim, Reina Teegan Gallagher, Susan Clement, Darren Brind, Alison Watts, Gill Mupudzi, Mcdonald Wright, Mark Gitahi, Jane Gordon, Fiona Gocher, Denis Unitt, Esther Pateman, Hilary Batham, Sally Delahooke, Toby Grant, Allister Conder, Jill Higham, Andrew Cox, Mark O'Donohoe, Lynn Currie, Lynn King, Alistair Oblak, Metod Collins, Carole Whalley, Simon Quinn, Marie Baird, Yolanda Amey, Isobel Fraser, Jocelyn Li, Andy Cotterill, Donna Bell, Andrew Singhal, Amit Gee, Ian Greer, Sandra Ang, Yeng Ransford, Rupert Allison, Joanna Gotto, James Dyer, Simon Sweeting, Helen Millson, Charles Labbadia, Giancarlo Bragazzi, Maria Consiglia Andreone, Pietro Azzaroli, Francesco Galli, Andrea Tarocchi, Mirko Gasbarrini, Antonio GRIECO, ANTONIO Marrone, Giuseppe Donato, Maria Francesca Valenti, Luca Maroni, Luca Rigamonti, Cristina Picciotto, Antonino
Publication Year :
2018
Abstract
Background: Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters. Methods: We did logistic regression analysis of pretreatment variables in a discovery cohort of patients in the UK with primary biliary cholangitis to derive the best-fitting model of UDCA response, defined as alkaline phosphatase less than 1·67 times the upper limit of normal (ULN), measured after 12 months of treatment with UDCA. We validated the model in an external cohort of patients with primary biliary cholangitis and treated with UDCA in Italy. Additionally, we assessed correlations between model predictions and key histological features, such as biliary injury and fibrosis, on liver biopsy samples. Findings: 2703 participants diagnosed with primary biliary cholangitis between Jan 1, 1998, and May 31, 2015, were included in the UK-PBC cohort for derivation of the model. The following pretreatment parameters were associated with lower probability of UDCA response: higher alkaline phosphatase concentration (p<0·0001), higher total bilirubin concentration (p=0·0003), lower aminotransferase concentration (p=0·0012), younger age (p<0·0001), longer interval from diagnosis to the start of UDCA treatment (treatment time lag, p<0·0001), and worsening of alkaline phosphatase concentration from diagnosis (p<0·0001). Based on these variables, we derived a predictive score of UDCA response. In the external validation cohort, 460 patients diagnosed with primary biliary cholangitis were treated with UDCA, with follow-up data until May 31, 2016. In this validation cohort, the area under the re
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1358911120
Document Type :
Electronic Resource