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Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy:An Individual Participant Data Meta-Analysis
- Source :
- Bliddal , S , Derakhshan , A , Xiao , Y , Chen , L-M , Mannisto , T , Ashoor , G , Tao , F , Brown , S J , Vafeiadi , M , Itoh , S , Grineva , E N , Taylor , P , Ghafoor , F , Vaidya , B , Hattersley , A , Mosso , L , Oken , E , Kishi , R , Alexander , E K , Maraka , S , Huang , K , Chaker , L , Bassols , J , Pirzada , A , Lopez-Bermejo , A , Boucai , L , Peeters , R P , Pearce , E N , Nelson , S M , Chatzi , L , Vrijkotte , T G , Popova , P V , Walsh , J P , Nicolaides , K H , Suvanto , E , Lu , X , Pop , V J M , Forman , J L , Korevaar , T I M & Feldt-Rasmussen , U 2022 , ' Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy : An Individual Participant Data Meta-Analysis ' , Thyroid , vol. 32 , no. 7 , pp. 828-840 .
- Publication Year :
- 2022
-
Abstract
- Objectives: Thyroid autoimmunity is common in pregnant women and associated with thyroid dysfunction and adverse obstetric outcomes. Most studies focus on thyroid peroxidase antibodies (TPOAbs) assessed by a negative-positive dichotomy and rarely take into account thyroglobulin antibodies (TgAbs). This study aimed at determining the association of TPOAbs and TgAbs, respectively, and interdependently, with maternal thyroid function.Methods: This was a meta-analysis of individual participant cross-sectional data from 20 cohorts in the Consortium on Thyroid and Pregnancy. Women with multiple pregnancy, pregnancy by assisted reproductive technology, history of thyroid disease, or use of thyroid interfering medication were excluded. Associations of (log2) TPOAbs and TgAbs (with/without mutual adjustment) with cohort-specific z-scores of (log2) thyrotropin (TSH), free triiodothyronine (fT3), total triiodothyronine (TT3), free thyroxine (fT4), total thyroxine (TT4), or triiodothyronine:thyroxine (T3:T4) ratio were evaluated in a linear mixed model.Results: In total, 51,138 women participated (51,094 had TPOAb-data and 27,874 had TgAb-data). Isolated TPOAb positivity was present in 4.1% [95% confidence interval, CI: 3.0 to 5.2], isolated TgAb positivity in 4.8% [CI: 2.9 to 6.6], and positivity for both antibodies in 4.7% [CI: 3.1 to 6.3]. Compared with antibody-negative women, TSH was higher in women with isolated TPOAb positivity (z-score increment 0.40, CI: 0.16 to 0.64) and TgAb positivity (0.21, CI: 0.10 to 0.32), but highest in those positive for both antibodies (0.54, CI: 0.36 to 0.71). There was a dose-response effect of higher TPOAb and TgAb concentrations with higher TSH (TSH z-score increment for TPOAbs 0.12, CI: 0.09 to 0.15, TgAbs 0.08, CI: 0.02 to 0.15). When adjusting analyses for the other antibody, only the association of TPOAbs remained statistically significant. A higher TPOAb concentration was associated with lower fT4 (p < 0.001) and higher T3:T4 r
Details
- Database :
- OAIster
- Journal :
- Bliddal , S , Derakhshan , A , Xiao , Y , Chen , L-M , Mannisto , T , Ashoor , G , Tao , F , Brown , S J , Vafeiadi , M , Itoh , S , Grineva , E N , Taylor , P , Ghafoor , F , Vaidya , B , Hattersley , A , Mosso , L , Oken , E , Kishi , R , Alexander , E K , Maraka , S , Huang , K , Chaker , L , Bassols , J , Pirzada , A , Lopez-Bermejo , A , Boucai , L , Peeters , R P , Pearce , E N , Nelson , S M , Chatzi , L , Vrijkotte , T G , Popova , P V , Walsh , J P , Nicolaides , K H , Suvanto , E , Lu , X , Pop , V J M , Forman , J L , Korevaar , T I M & Feldt-Rasmussen , U 2022 , ' Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy : An Individual Participant Data Meta-Analysis ' , Thyroid , vol. 32 , no. 7 , pp. 828-840 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1349066652
- Document Type :
- Electronic Resource