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Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformations
- Publication Year :
- 2005
-
Abstract
- Kaposi's Sarcoma (KS) is an angioproliferative disease associated with human herpesvirus 8 (HHV-8) infection. We have characterized the morphologic and phenotypic modifications of HUVEC in a model of productive HHV-8 infection. HHV-8 replication was associated with ultra-structural changes, flattened soma and a loss of marginal folds and intercellular contacts, and morphologic features, spindle cell conversion and cordon-like structures formation. Phenotypic changes observed on cordon-like structures included partial loss and redistribution of CD31/PECAM-1 and VE-cadherin, uPAR up-regulation and de novo expression of CD13/APN. Such changes demonstrate the induction, in HUVEC, of an angiogenic profile. Most of these findings are directly linked to HHV-8-encoded proteins expression, suggesting that HHV-8 itself may participate to the initial steps of the angiogenic transformation in KS
Details
- Database :
- OAIster
- Notes :
- Foglieni, C, Scabini, S, Belloni, D, Broccolo, F, Lusso, P, Malnati, M, Ferrero, E, Foglieni, C, Scabini, S, Belloni, D, Lusso, P, Malnati, MS, Ferrero, E., BROCCOLO, FRANCESCO
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1346403920
- Document Type :
- Electronic Resource