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Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer:a randomized controlled trial (PAM study)

Authors :
Koevoets, E. W.
Schagen, S. B.
de Ruiter, M. B.
Geerlings, M. I.
Witlox, L.
van der Wall, E.
Stuiver, M. M.
Sonke, G. S.
Velthuis, M. J.
Jobsen, J. J.
Menke-Pluijmers, M. B.E.
Göker, E.
van der Pol, C. C.
Bos, M. E.M.M.
Tick, L. W.
van Holsteijn, N. A.
van der Palen, J.
May, A. M.
Monninkhof, E. M.
Koevoets, E. W.
Schagen, S. B.
de Ruiter, M. B.
Geerlings, M. I.
Witlox, L.
van der Wall, E.
Stuiver, M. M.
Sonke, G. S.
Velthuis, M. J.
Jobsen, J. J.
Menke-Pluijmers, M. B.E.
Göker, E.
van der Pol, C. C.
Bos, M. E.M.M.
Tick, L. W.
van Holsteijn, N. A.
van der Palen, J.
May, A. M.
Monninkhof, E. M.
Source :
Koevoets , E W , Schagen , S B , de Ruiter , M B , Geerlings , M I , Witlox , L , van der Wall , E , Stuiver , M M , Sonke , G S , Velthuis , M J , Jobsen , J J , Menke-Pluijmers , M B E , Göker , E , van der Pol , C C , Bos , M E M M , Tick , L W , van Holsteijn , N A , van der Palen , J , May , A M & Monninkhof , E M 2022 , ' Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer : a randomized controlled trial (PAM study) ' , Breast Cancer Research , vol. 24 , no. 1 , 36 .
Publication Year :
2022

Abstract

Background: Up to 60% of breast cancer patients treated with chemotherapy is confronted with cognitive problems, which can have a significant impact on daily activities and quality of life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed breast cancer patients 2–4 years after diagnosis. Methods: Chemotherapy-exposed breast cancer patients, with both self-reported cognitive problems and lower than expected performance on neuropsychological tests, were randomized to an exercise or control group. The 6-month exercise intervention consisted of supervised aerobic and strength training (2 h/week), and Nordic/power walking (2 h/week). Our primary outcome was memory functioning (Hopkins Verbal Learning Test-Revised; HVLT-R). Secondary outcomes included online neuropsychological tests (Amsterdam Cognition Scan; ACS), self-reported cognition (MD Anderson Symptom Inventory for multiple myeloma; MDASI-MM), physical fitness (relative maximum oxygen uptake; VO2peak), fatigue (Multidimensional Fatigue Inventory), QoL (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire; EORTC QLQ C-30), depression (Patient Health Questionnaire-9, Hospital Anxiety and Depression Scale; HADS), and anxiety (HADS). HVLT-R total recall was analyzed with a Fisher exact test for clinically relevant improvement (≥ 5 words). Other outcomes were analyzed using multiple regression analyses adjusted for baseline and stratification factors. Results: We randomized 181 patients to the exercise (n = 91) or control group (n = 90). Two-third of the patients attended ≥ 80% of the exercise sessions, and physical fitness significantly improved compared to control patients (B VO2peak 1.4 ml/min/kg, 95%CI:0.6;2.2). No difference in favor of the intervention group was seen on the primary outcome. Significant beneficial intervention effects were found for self-reported cognitive functioning [MDASI

Details

Database :
OAIster
Journal :
Koevoets , E W , Schagen , S B , de Ruiter , M B , Geerlings , M I , Witlox , L , van der Wall , E , Stuiver , M M , Sonke , G S , Velthuis , M J , Jobsen , J J , Menke-Pluijmers , M B E , Göker , E , van der Pol , C C , Bos , M E M M , Tick , L W , van Holsteijn , N A , van der Palen , J , May , A M & Monninkhof , E M 2022 , ' Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer : a randomized controlled trial (PAM study) ' , Breast Cancer Research , vol. 24 , no. 1 , 36 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1343122164
Document Type :
Electronic Resource