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Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer:a randomized controlled trial (PAM study)
- Source :
- Koevoets , E W , Schagen , S B , de Ruiter , M B , Geerlings , M I , Witlox , L , van der Wall , E , Stuiver , M M , Sonke , G S , Velthuis , M J , Jobsen , J J , Menke-Pluijmers , M B E , Göker , E , van der Pol , C C , Bos , M E M M , Tick , L W , van Holsteijn , N A , van der Palen , J , May , A M & Monninkhof , E M 2022 , ' Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer : a randomized controlled trial (PAM study) ' , Breast Cancer Research , vol. 24 , no. 1 , 36 .
- Publication Year :
- 2022
-
Abstract
- Background: Up to 60% of breast cancer patients treated with chemotherapy is confronted with cognitive problems, which can have a significant impact on daily activities and quality of life (QoL). We investigated whether exercise training improves cognition in chemotherapy-exposed breast cancer patients 2–4 years after diagnosis. Methods: Chemotherapy-exposed breast cancer patients, with both self-reported cognitive problems and lower than expected performance on neuropsychological tests, were randomized to an exercise or control group. The 6-month exercise intervention consisted of supervised aerobic and strength training (2 h/week), and Nordic/power walking (2 h/week). Our primary outcome was memory functioning (Hopkins Verbal Learning Test-Revised; HVLT-R). Secondary outcomes included online neuropsychological tests (Amsterdam Cognition Scan; ACS), self-reported cognition (MD Anderson Symptom Inventory for multiple myeloma; MDASI-MM), physical fitness (relative maximum oxygen uptake; VO2peak), fatigue (Multidimensional Fatigue Inventory), QoL (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire; EORTC QLQ C-30), depression (Patient Health Questionnaire-9, Hospital Anxiety and Depression Scale; HADS), and anxiety (HADS). HVLT-R total recall was analyzed with a Fisher exact test for clinically relevant improvement (≥ 5 words). Other outcomes were analyzed using multiple regression analyses adjusted for baseline and stratification factors. Results: We randomized 181 patients to the exercise (n = 91) or control group (n = 90). Two-third of the patients attended ≥ 80% of the exercise sessions, and physical fitness significantly improved compared to control patients (B VO2peak 1.4 ml/min/kg, 95%CI:0.6;2.2). No difference in favor of the intervention group was seen on the primary outcome. Significant beneficial intervention effects were found for self-reported cognitive functioning [MDASI
Details
- Database :
- OAIster
- Journal :
- Koevoets , E W , Schagen , S B , de Ruiter , M B , Geerlings , M I , Witlox , L , van der Wall , E , Stuiver , M M , Sonke , G S , Velthuis , M J , Jobsen , J J , Menke-Pluijmers , M B E , Göker , E , van der Pol , C C , Bos , M E M M , Tick , L W , van Holsteijn , N A , van der Palen , J , May , A M & Monninkhof , E M 2022 , ' Effect of physical exercise on cognitive function after chemotherapy in patients with breast cancer : a randomized controlled trial (PAM study) ' , Breast Cancer Research , vol. 24 , no. 1 , 36 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1343122164
- Document Type :
- Electronic Resource