A 3D Interconnected Microchannel Network Formed in Gelatin by Sacrificial Shellac Microfibers

3D microfluidic networks are fabricated in a gelatin hydrogel using sacrificial melt-spun microfibers made from a material with pH-dependent solubility. The fibers, after being embedded within the gel, can be removed by changing the gel pH to induce dissolution. This process is performed in an entirely aqueous environment, avoiding extreme temperatures, low pressures, and toxic organic solvents. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.