Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea

Andras Bikov,1,2 Stefan Frent,3 Daniela Reisz,4 Alina Negru,5,6 Laura Gaita,7 Daniel Breban Schwarzkopf,8 Stefan Mihaicuta3 1North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK; 2Division of Immunology, Immunity to Infection and Respiratory Medicine, University of Manchester, Manchester, UK; 3Center for Research and Innovation in Precision Medicine of Respiratory Diseases, Department of Pulmonology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 4Department of Neurology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 5Department of Cardiology (II), “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 6Department of Clinical Research, Institute of Cardiovascular Diseases, Timisoara, Romania; 7Second Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 8Department of Anatomy, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, RomaniaCorrespondence: Stefan Frent; Daniela Reisz, Email frentz.stefan@umft.ro; reisz.daniela@umft.roPurpose: Obstructive sleep apnoea (OSA) is a recognised risk factor for cardiovascular disease. However, it is difficult to evaluate the risk of cardiovascular disease in patients with OSA due to multiple shared risk factors. Composite lipid indices, such as atherogenic index of plasma (AIP), visceral adiposity index (VAI) and lipid accumulation product (LAP) have been shown to predict cardiovascular disease better than their individual lipid components. This study aimed to evaluate these indices in patients with OSA.Patients and Methods: Six hundred sixty-seven (667) patients with OSA and 139 non-OSA control volunteers participated in the study. Fasting serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C) levels were measured