Sleep Disturbances Before Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus

Yifan Song,1,* Liping Wang,2,* Danni Zheng,3,4 Lin Zeng,5 Yan Wang3,4 1Department of General Practice, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 2Department of Neurology, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 3Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 4National Clinical Research Center for Obstetrics and Gynecology, Beijing, 100191, People’s Republic of China; 5Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Wang, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100026, People’s Republic of China, Tel +13311165106, Email wjgqhn@263.net Lin Zeng, Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, People’s Republic of China, +86 13811401686, Email zlwhy@163.comPurpose: To investigate the relationship between sleep disturbances before pregnancy and the subsequent risk for gestational diabetes mellitus (GDM).Patients and Methods: Pregnant women who attended antenatal clinic before the 12th gestational week between September 2019 and June 2020 were enrolled. The sleep status at the month before the last menstrual period was collected by filling the Pittsburgh Sleep Quality Index (PSQI) and Berlin Questionnaire (BQ) to evaluate the sleep duration, quality and the risk of obstructive sleep apnea (OSA). With monthly antenatal care, the oral glucose tolerance test (OGTT) was performed during 24– 28 gestational weeks. According to the results, GDM and non-GDM group were classified. The sleep status and baseline characters were compared between the two groups.Results: A total of 355 pregnant women wer