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Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes
- Source :
- Vogelezang , S , Bradfield , J P , Early Growth Genetics Consortium , Ahluwalia , T V S , Liu , X , Schnurr , T M , Frithioff-Bøjsøe , C , Bønnelykke , K , Lind , M V , Lauritzen , L , Michaelsen , K F , Lund , M A V , Melbye , M , Morgen , C S , Pedersen , O B , Holm , J-C , Grarup , N , Hansen , T , Nohr , E A , Bisgaard , H , Grant , S F A , Felix , J F & Jaddoe , V W V 2022 , ' Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes ' , BMC Medical Genomics , vol. 15 , 124 .
- Publication Year :
- 2022
-
Abstract
- Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
Details
- Database :
- OAIster
- Journal :
- Vogelezang , S , Bradfield , J P , Early Growth Genetics Consortium , Ahluwalia , T V S , Liu , X , Schnurr , T M , Frithioff-Bøjsøe , C , Bønnelykke , K , Lind , M V , Lauritzen , L , Michaelsen , K F , Lund , M A V , Melbye , M , Morgen , C S , Pedersen , O B , Holm , J-C , Grarup , N , Hansen , T , Nohr , E A , Bisgaard , H , Grant , S F A , Felix , J F & Jaddoe , V W V 2022 , ' Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes ' , BMC Medical Genomics , vol. 15 , 124 .
- Notes :
- Vogelezang, Suzanne, Bradfield, Jonathan P, Ahluwalia, Tarun Veer Singh, Liu, Xueping, Schnurr, Theresia Maria, Frithioff-Bøjsøe, Christine, Bønnelykke, Klaus, Lind, Mads Vendelbo, Lauritzen, Lotte, Michaelsen, Kim F., Lund, Morten Asp Vonsild, Melbye, Mads, Morgen, Camilla Schmidt, Pedersen, Oluf Borbye, Holm, Jens-Christian, Grarup, Niels, Hansen, Torben, Nohr, Ellen A, Bisgaard, Hans, Grant, Struan F A, Felix, Janine F, Jaddoe, Vincent W V
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1340144321
- Document Type :
- Electronic Resource