Back to Search
Start Over
Using beta-lactamase to trigger supramolecular hydrogelation
- Publication Year :
- 2007
-
Abstract
- This paper reports the rational design and synthesis of a beta-lactam conjugate. Treating the conjugate with beta-lactamase cleaves the scissile -lactam amide bond, releases a hydrogelator, and results in enzymatic formation of a supramolecular hydrogel. The process involves the use of a bacterial enzyme-the one causes antibiotic inactivation and accounts for resistance to beta-lactams in many clinical important pathogens-to catalyze the formation of the hydrogel. It offers an opportunity to investigate the kinetics of these types of enzymatic reactions, screen inhibitors of the enzyme, and provides a new candidate to generate hydrogels for biomedical applications.
Details
- Database :
- OAIster
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1331208439
- Document Type :
- Electronic Resource