Thinking twice before abandoning first-line chemotherapy in ovarian cancer: Report of two cases and literature review. Passing from tri-weekly to weekly regimens

We present two cases of advanced ovarian cancer treated with neoadjuvant chemotherapy with standard tri-weekly carboplatin and paclitaxel. Therapy was converted to weekly regimens because of disease progression, resulting in disease response. Weekly regimens could overcome drug resistance and this strategy should be attempted before abandoning first-line chemotherapy in favor of palliation. © Japan Society of Clinical Oncology 2012.