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ProCaLung - Peer review in stage III, mediastinal node-positive, non-small-cell lung cancer: How to benchmark clinical practice of nodal target volume definition and delineation in Belgium.

ProCaLung - Peer review in stage III, mediastinal node-positive, non-small-cell lung cancer: How to benchmark clinical practice of nodal target volume definition and delineation in Belgium.

Authors :
UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (MGD) Service d'oncologie médicale
Charlier, Florian
Descamps, Thomas
Lievens, Yolande
Geets, Xavier
Remouchamps, Vincent
Lambrecht, Maarten
Moretti, Luigi
UCL - SSS/IREC/MONT - Pôle Mont Godinne
UCL - (MGD) Service d'oncologie médicale
Charlier, Florian
Descamps, Thomas
Lievens, Yolande
Geets, Xavier
Remouchamps, Vincent
Lambrecht, Maarten
Moretti, Luigi
Source :
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 167, p. 57-64 (2022)
Publication Year :
2022

Abstract

The Quality Assurance project for stage III non-small cell lung cancer radiotherapy ProCaLung performed a multicentric two-step exercise evaluating mediastinal nodal Target Volume Definition and Delineation (TVD) variability and the opportunity for standardization. The TVD variability before and after providing detailed guidelines and the value of qualitative contour reviewing before applying quantitative measures were investigated. The case of a patient with stage III NSCLC and involved mediastinal lymph nodes was used as a basis for this study. Twenty-two radiation oncologists from nineteen centers in Belgium and Luxembourg participated in at least one of two phases of the project (before and after introduction of ProCaLung contouring guidelines). The resulting thirty-three mediastinal nodal GTV and CTV contours were then evaluated using a qualitative-before-quantitative (QBQ) approach. First, a qualitative analysis was performed, evaluating adherence to most recent guidelines. From this, a list of observed deviations was created and these were used to evaluate contour conformity. The second analysis was quantitative, using overlap and surface distance measures to compare contours within qualitative groups and between phases. A 'most robust' reference volume for these analyses was created using the STAPLE-algorithm and an averaging method. Five GTV and seven CTV qualitative groups were identified. Second step contours were more often in higher-conformity groups (p = 0.012 for GTV and p = 0.024 for CTV). Median Residual Mean Square Distances improved from 2.34 mm to 1.36 mm for GTV (p = 0.01) and from 4.53 mm to 1.58 mm for CTV (p < 0.0001). Median Dice coefficients increased from 0.81 to 0.84 for GTV (p = 0.07) and from 0.82 to 0.89 for CTV (p ≤ 0.001). Using HC-contours only to generate references translated in more robust quantitative evaluations. Variability of mediastinal nodal TVD was reduced after providing the ProCaLung consensus guidelines. A qualitative r

Details

Database :
OAIster
Journal :
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 167, p. 57-64 (2022)
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1328222937
Document Type :
Electronic Resource