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In silico screening: identification of a novel CDK-1 inhibitor from Chrysophyllum cainito leaves
- Source :
- International Journal of Progressive Research in Science and Engineering ; Vol. 3 No. 05 (2022): May; 21-24; 2582-7898
- Publication Year :
- 2022
-
Abstract
- Increasing evidence suggests that OSCC overexpresses CDK-1 to promote its advancement, which intervene in the paclitaxel effects. As a result of drug resistance and immune evasion, treating the advanced stage of OSCC has proven challenging. Therefore, a CDK-1 inhibitor with high inhibitory activity, excellent pharmacokinetic activities, and minimal adverse effects is urgently needed. Our study has uncovered novel CDK-1 inhibitors, which would be beneficial and expected to reinstate the paclitaxel-resistant while treating combined with our novel inhibitors in the future.   &nbsp
Details
- Database :
- OAIster
- Journal :
- International Journal of Progressive Research in Science and Engineering ; Vol. 3 No. 05 (2022): May; 21-24; 2582-7898
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1327722205
- Document Type :
- Electronic Resource