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Combination antifungal therapy without craniotomy in an immunocompromised patient with rhino-orbito-cerebral mucormycosis:A case report

Authors :
Salehi, Mohammadreza
Shahi, Farhad
Rizvi, Fatema Sadaat
Ghaderkhani, Sara
Zainaldain, Hamed
Khodavaisy, Sadegh
Jamali-Moghaddam, Saeed Reza
Dehghan Manshadi, Seyed Ali
Rezahosseini, Omid
Salehi, Mohammadreza
Shahi, Farhad
Rizvi, Fatema Sadaat
Ghaderkhani, Sara
Zainaldain, Hamed
Khodavaisy, Sadegh
Jamali-Moghaddam, Saeed Reza
Dehghan Manshadi, Seyed Ali
Rezahosseini, Omid
Source :
Salehi , M , Shahi , F , Rizvi , F S , Ghaderkhani , S , Zainaldain , H , Khodavaisy , S , Jamali-Moghaddam , S R , Dehghan Manshadi , S A & Rezahosseini , O 2020 , ' Combination antifungal therapy without craniotomy in an immunocompromised patient with rhino-orbito-cerebral mucormycosis : A case report ' , Caspian Journal of Internal Medicine , vol. 11 , no. 2 , pp. 227-230 .
Publication Year :
2020

Abstract

Background: Mucormycosis is an uncommon fungal infection caused by the members of the order Mucorales. In susceptible patients, mucormycosis can infect any tissue or organ, and without suitable treatment (i.e., debridement and antifungal therapy), this infection can be fatal. Our patient was a woman with lymphoma and cerebral mucormycosis who was treated with antifungals and without any neurosurgical debridement.Case Presentation: Herein, we present the case of a 35-year-old woman with diagnosis of B-cell lymphoma and rhino-orbito-cerebral mucormycosis (ROCM). She was a candidate for enucleation of the left eye, orbital decompression, and sinocerebral debridement. Nevertheless, the patient refused eye enucleation and craniotomy. Finally, she was treated with a combination of antifungals and sinus debridement without eye enucleation and craniotomy.Conclusion: debridement, along with a combination of liposomal amphotericin B (LAMB) and posaconazole, may be a suitable therapeutic option for patients with ROCM, who are not eligible candidates for extensive surgery or craniotomy.

Details

Database :
OAIster
Journal :
Salehi , M , Shahi , F , Rizvi , F S , Ghaderkhani , S , Zainaldain , H , Khodavaisy , S , Jamali-Moghaddam , S R , Dehghan Manshadi , S A & Rezahosseini , O 2020 , ' Combination antifungal therapy without craniotomy in an immunocompromised patient with rhino-orbito-cerebral mucormycosis : A case report ' , Caspian Journal of Internal Medicine , vol. 11 , no. 2 , pp. 227-230 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1322747834
Document Type :
Electronic Resource