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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Authors :
Ligthart, Symen
Vaez, Ahmad
Vosa, Urmo
Stathopoulou, Maria G.
de Vries, Paul S.
Prins, Bram P.
Van der Most, Peter J.
Tanaka, Toshiko
Naderi, Elnaz
Rose, Lynda M.
Wu, Ying
Karlsson, Robert
Barbalic, Maja
Lin, Honghuang
Pool, Rene
Zhu, Gu
Mace, Aurelien
Sidore, Carlo
Trompet, Stella
Mangino, Massimo
Sabater-Lleal, Maria
Kemp, John P.
Abbasi, Ali
Kacprowski, Tim
Verweij, Niek
Smith, Albert V.
Huang, Tao
Marzi, Carola
Feitosa, Mary F.
Lohman, Kurt K.
Kleber, Marcus E.
Milaneschi, Yuri
Mueller, Christian
Huq, Mahmudul
Vlachopoulou, Efthymia
Lyytikainen, Leo-Pekka
Oldmeadow, Christopher
Deelen, Joris
Perola, Markus
Zhao, Jing
Feenstra, Bjarke
Amini, Marzyeh
Lahti, Jari
Schraut, Katharina E.
Fornage, Myriam
Suktitipat, Bhoom
Chen, Wei-Min
Li, Xiaohui
Nutile, Teresa
Malerba, Giovanni
Luan, Jian'an
Bak, Tom
Schork, Nicholas
Del Greco, Fabiola M.
Thiering, Elisabeth
Mahajan, Anubha
Marioni, Riccardo E.
Mihailov, Evelin
Eriksson, Joel
Ozel, Ayse Bilge
Zhang, Weihua
Nethander, Maria
Cheng, Yu-Ching
Aslibekyan, Stella
Ang, Wei
Gandin, Ilaria
Yengo, Loic
Portas, Laura
Kooperberg, Charles
Hofer, Edith
Rajan, Kumar B.
Schurmann, Claudia
den Hollander, Wouter
Ahluwalia, Tarunveer S.
Draisma, Harmen H. M.
Ford, Ian
Timpson, Nicholas
Teumer, Alexander
Huang, Hongyan
Wahl, Simone
Liu, YongMei
Huang, Jie
Uh, Hae-Won
Geller, Frank
Joshi, Peter K.
Yanek, Lisa R.
Trabetti, Elisabetta
Lehne, Benjamin
Vozzi, Diego
Verbanck, Marie
Biino, Ginevra
Saba, Yasaman
Meulenbelt, Ingrid
O'Connell, Jeff R.
Laakso, Markku
Giulianini, Franco
Magnusson, Patrik K. E.
Ballantyne, Christie M.
Hottenga, Jouke Jan
Montgomery, GrantW.
Rivadineira, Fernando
Rueedi, Rico
Steri, Maristella
Herzig, Karl-Heinz
Stott, David J.
Menni, Cristina
Franberg, Mattias
St Pourcain, Beate
Felix, Stephan B.
Pers, Tune H.
Bakker, Stephan J. L.
Kraft, Peter
Peters, Annette
Vaidya, Dhananjay
Delgado, Graciela
Smit, Johannes H.
Grossmann, Vera
Sinisalo, Juha
Seppala, Ilkka
Williams, Stephen R.
Holliday, Elizabeth G.
Moed, Matthijs
Langenberg, Claudia
Raikkonen, Katri
Ding, Jingzhong
Campbell, Harry
Sale, Michele M.
Chen, Yii-Der I.
James, Alan L.
Ruggiero, Daniela
Soranzo, Nicole
Hartman, Catharina A.
Smith, Erin N.
Berenson, Gerald S.
Fuchsberger, Christian
Hernandez, Dena
Tiesler, Carla M. T.
Giedraitis, Vilmantas
Liewald, David
Fischer, Krista
Mellstrom, Dan
Larsson, Anders
Wang, Yunmei
Scott, William R.
Lorentzon, Matthias
Beilby, John
Ryan, Kathleen A.
Pennell, Craig E.
Vuckovic, Dragana
Balkau, Beverly
Concas, Maria Pina
Schmidt, Reinhold
de Leon, Carlos F. Mendes
Bottinger, Erwin P.
Kloppenburg, Margreet
Paternoster, Lavinia
Boehnke, Michael
Musk, A. W.
Willemsen, Gonneke
Evans, David M.
Madden, Pamela A. F.
Kahonen, Mika
Kutalik, Zoltan
Zoledziewska, Magdalena
Karhunen, Ville
Kritchevsky, Stephen B.
Sattar, Naveed
Lachance, Genevieve
Clarke, Robert
Harris, Tamara B.
Raitakari, Olli T.
Attia, John R.
Van Heemst, Diana
Kajantie, Eero
Sorice, Rossella
Gambaro, Giovanni
Scott, Robert A.
Hicks, Andrew A.
Ferrucci, Luigi
Standl, Marie
Lindgren, Cecilia M.
Starr, John M.
Karlsson, Magnus
Lind, Lars
Li, Jun Z.
Chambers, John C.
Mori, Trevor A.
de Geus, Eco J. C. N.
Heath, Andrew C.
Martin, Nicholas G.
Auvinen, Juha
Buckley, Brendan M.
de Craen, Anton J. M.
Waldenberger, Melanie
Strauch, Konstantin
Meitinger, Thomas
Scott, Rodney J.
McEvoy, Mark
Beekman, Marian
Bombieri, Cristina
Ridker, Paul M.
Mohlke, Karen L.
Pedersen, Nancy L.
Morrison, Alanna C.
Boomsma, Dorret I.
Whitfield, John B.
Strachan, David P.
Hofman, Albert
Vollenweider, Peter
Cucca, Francesco
Jarvelin, Marjo-Riitta
Jukema, J. Wouter
Spector, Tim D.
Hamsten, Anders
Zeller, Tanja
Uitterlinden, Andre G.
Nauck, Matthias
Gudnason, Vilmundur
Qi, Lu
Grallert, Harald
Borecki, Ingrid B.
Rotter, Jerome I.
Maerz, Winfried
Wild, Philipp S.
Lokki, Marja-Liisa
Boyle, Michael
Salomaa, Veikko
Melbye, Mads
Eriksson, Johan G.
Wilson, James F.
Penninx, Brenda W. J. H.
Becker, Diane M.
Worrall, Bradford B.
Gibson, Greg
Krauss, Ronald M.
Ciullo, Marina
Zaza, Gianluigi
Wareham, Nicholas J.
Oldehinkel, Albertine J.
Palmer, Lyle J.
Murray, Sarah S.
Pramstaller, Peter P.
Bandinelli, Stefania
Heinrich, Joachim
Ingelsson, Erik
Deary, Ian J.
Magi, Reedik
Vandenput, Liesbeth
van der Harst, Pim
Desch, Karl C.
Kooner, Jaspal S.
Ohlsson, Claes
Hayward, Caroline
Lehtimaki, Terho
Shuldiner, Alan R.
Arnett, Donna K.
Beilin, Lawrence J.
Robino, Antonietta
Froguel, Philippe
Pirastu, Mario
Jess, Tine
Koenig, Wolfgang
Loos, Ruth J. F.
Evans, Denis A.
Schmidt, Helena
Smith, George Davey
Slagboom, P. Eline
Eiriksdottir, Gudny
Morris, Andrew P.
Psaty, Bruce M.
Tracy, Russell P.
Nolte, Ilja M.
Boerwinkle, Eric
Visvikis-Siest, Sophie
Reiner, Alex P.
Gross, Myron
Bis, Joshua C.
Franke, Lude
Franco, Oscar H.
Benjamin, Emelia J.
Chasman, Daniel I.
Dupuis, Josee
Snieder, Harold
Dehghan, Abbas
Alizadeh, Behrooz Z.
Ligthart, Symen
Vaez, Ahmad
Vosa, Urmo
Stathopoulou, Maria G.
de Vries, Paul S.
Prins, Bram P.
Van der Most, Peter J.
Tanaka, Toshiko
Naderi, Elnaz
Rose, Lynda M.
Wu, Ying
Karlsson, Robert
Barbalic, Maja
Lin, Honghuang
Pool, Rene
Zhu, Gu
Mace, Aurelien
Sidore, Carlo
Trompet, Stella
Mangino, Massimo
Sabater-Lleal, Maria
Kemp, John P.
Abbasi, Ali
Kacprowski, Tim
Verweij, Niek
Smith, Albert V.
Huang, Tao
Marzi, Carola
Feitosa, Mary F.
Lohman, Kurt K.
Kleber, Marcus E.
Milaneschi, Yuri
Mueller, Christian
Huq, Mahmudul
Vlachopoulou, Efthymia
Lyytikainen, Leo-Pekka
Oldmeadow, Christopher
Deelen, Joris
Perola, Markus
Zhao, Jing
Feenstra, Bjarke
Amini, Marzyeh
Lahti, Jari
Schraut, Katharina E.
Fornage, Myriam
Suktitipat, Bhoom
Chen, Wei-Min
Li, Xiaohui
Nutile, Teresa
Malerba, Giovanni
Luan, Jian'an
Bak, Tom
Schork, Nicholas
Del Greco, Fabiola M.
Thiering, Elisabeth
Mahajan, Anubha
Marioni, Riccardo E.
Mihailov, Evelin
Eriksson, Joel
Ozel, Ayse Bilge
Zhang, Weihua
Nethander, Maria
Cheng, Yu-Ching
Aslibekyan, Stella
Ang, Wei
Gandin, Ilaria
Yengo, Loic
Portas, Laura
Kooperberg, Charles
Hofer, Edith
Rajan, Kumar B.
Schurmann, Claudia
den Hollander, Wouter
Ahluwalia, Tarunveer S.
Draisma, Harmen H. M.
Ford, Ian
Timpson, Nicholas
Teumer, Alexander
Huang, Hongyan
Wahl, Simone
Liu, YongMei
Huang, Jie
Uh, Hae-Won
Geller, Frank
Joshi, Peter K.
Yanek, Lisa R.
Trabetti, Elisabetta
Lehne, Benjamin
Vozzi, Diego
Verbanck, Marie
Biino, Ginevra
Saba, Yasaman
Meulenbelt, Ingrid
O'Connell, Jeff R.
Laakso, Markku
Giulianini, Franco
Magnusson, Patrik K. E.
Ballantyne, Christie M.
Hottenga, Jouke Jan
Montgomery, GrantW.
Rivadineira, Fernando
Rueedi, Rico
Steri, Maristella
Herzig, Karl-Heinz
Stott, David J.
Menni, Cristina
Franberg, Mattias
St Pourcain, Beate
Felix, Stephan B.
Pers, Tune H.
Bakker, Stephan J. L.
Kraft, Peter
Peters, Annette
Vaidya, Dhananjay
Delgado, Graciela
Smit, Johannes H.
Grossmann, Vera
Sinisalo, Juha
Seppala, Ilkka
Williams, Stephen R.
Holliday, Elizabeth G.
Moed, Matthijs
Langenberg, Claudia
Raikkonen, Katri
Ding, Jingzhong
Campbell, Harry
Sale, Michele M.
Chen, Yii-Der I.
James, Alan L.
Ruggiero, Daniela
Soranzo, Nicole
Hartman, Catharina A.
Smith, Erin N.
Berenson, Gerald S.
Fuchsberger, Christian
Hernandez, Dena
Tiesler, Carla M. T.
Giedraitis, Vilmantas
Liewald, David
Fischer, Krista
Mellstrom, Dan
Larsson, Anders
Wang, Yunmei
Scott, William R.
Lorentzon, Matthias
Beilby, John
Ryan, Kathleen A.
Pennell, Craig E.
Vuckovic, Dragana
Balkau, Beverly
Concas, Maria Pina
Schmidt, Reinhold
de Leon, Carlos F. Mendes
Bottinger, Erwin P.
Kloppenburg, Margreet
Paternoster, Lavinia
Boehnke, Michael
Musk, A. W.
Willemsen, Gonneke
Evans, David M.
Madden, Pamela A. F.
Kahonen, Mika
Kutalik, Zoltan
Zoledziewska, Magdalena
Karhunen, Ville
Kritchevsky, Stephen B.
Sattar, Naveed
Lachance, Genevieve
Clarke, Robert
Harris, Tamara B.
Raitakari, Olli T.
Attia, John R.
Van Heemst, Diana
Kajantie, Eero
Sorice, Rossella
Gambaro, Giovanni
Scott, Robert A.
Hicks, Andrew A.
Ferrucci, Luigi
Standl, Marie
Lindgren, Cecilia M.
Starr, John M.
Karlsson, Magnus
Lind, Lars
Li, Jun Z.
Chambers, John C.
Mori, Trevor A.
de Geus, Eco J. C. N.
Heath, Andrew C.
Martin, Nicholas G.
Auvinen, Juha
Buckley, Brendan M.
de Craen, Anton J. M.
Waldenberger, Melanie
Strauch, Konstantin
Meitinger, Thomas
Scott, Rodney J.
McEvoy, Mark
Beekman, Marian
Bombieri, Cristina
Ridker, Paul M.
Mohlke, Karen L.
Pedersen, Nancy L.
Morrison, Alanna C.
Boomsma, Dorret I.
Whitfield, John B.
Strachan, David P.
Hofman, Albert
Vollenweider, Peter
Cucca, Francesco
Jarvelin, Marjo-Riitta
Jukema, J. Wouter
Spector, Tim D.
Hamsten, Anders
Zeller, Tanja
Uitterlinden, Andre G.
Nauck, Matthias
Gudnason, Vilmundur
Qi, Lu
Grallert, Harald
Borecki, Ingrid B.
Rotter, Jerome I.
Maerz, Winfried
Wild, Philipp S.
Lokki, Marja-Liisa
Boyle, Michael
Salomaa, Veikko
Melbye, Mads
Eriksson, Johan G.
Wilson, James F.
Penninx, Brenda W. J. H.
Becker, Diane M.
Worrall, Bradford B.
Gibson, Greg
Krauss, Ronald M.
Ciullo, Marina
Zaza, Gianluigi
Wareham, Nicholas J.
Oldehinkel, Albertine J.
Palmer, Lyle J.
Murray, Sarah S.
Pramstaller, Peter P.
Bandinelli, Stefania
Heinrich, Joachim
Ingelsson, Erik
Deary, Ian J.
Magi, Reedik
Vandenput, Liesbeth
van der Harst, Pim
Desch, Karl C.
Kooner, Jaspal S.
Ohlsson, Claes
Hayward, Caroline
Lehtimaki, Terho
Shuldiner, Alan R.
Arnett, Donna K.
Beilin, Lawrence J.
Robino, Antonietta
Froguel, Philippe
Pirastu, Mario
Jess, Tine
Koenig, Wolfgang
Loos, Ruth J. F.
Evans, Denis A.
Schmidt, Helena
Smith, George Davey
Slagboom, P. Eline
Eiriksdottir, Gudny
Morris, Andrew P.
Psaty, Bruce M.
Tracy, Russell P.
Nolte, Ilja M.
Boerwinkle, Eric
Visvikis-Siest, Sophie
Reiner, Alex P.
Gross, Myron
Bis, Joshua C.
Franke, Lude
Franco, Oscar H.
Benjamin, Emelia J.
Chasman, Daniel I.
Dupuis, Josee
Snieder, Harold
Dehghan, Abbas
Alizadeh, Behrooz Z.
Source :
Ligthart , S , Vaez , A , Vosa , U , Stathopoulou , M G , de Vries , P S , Prins , B P , Van der Most , P J , Tanaka , T , Naderi , E , Rose , L M , Wu , Y , Karlsson , R , Barbalic , M , Lin , H , Pool , R , Zhu , G , Mace , A , Sidore , C , Trompet , S , Mangino , M , Sabater-Lleal , M , Kemp , J P , Abbasi , A , Kacprowski , T , Verweij , N , Smith , A V , Huang , T , Marzi , C , Feitosa , M F , Lohman , K K , Kleber , M E , Milaneschi , Y , Mueller , C , Huq , M , Vlachopoulou , E , Lyytikainen , L-P , Oldmeadow , C , Deelen , J , Perola , M , Zhao , J , Feenstra , B , Amini , M , Lahti , J , Schraut , K E , Fornage , M , Suktitipat , B , Chen , W-M , Li , X , Nutile , T , Malerba , G , Luan , J , Bak , T , Schork , N , Del Greco , F M , Thiering , E , Mahajan , A , Marioni , R E , Mihailov , E , Eriksson , J , Ozel , A B , Zhang , W , Nethander , M , Cheng , Y-C , Aslibekyan , S , Ang , W , Gandin , I , Yengo , L , Portas , L , Kooperberg , C , Hofer , E , Rajan , K B , Schurmann , C , den Hollander , W , Ahluwalia , T S , Zhao , J , Draisma , H H M , Ford , I , Timpson , N , Teumer , A , Huang , H , Wahl , S , Liu , Y , Huang , J , Uh , H-W , Geller , F , Joshi , P K , Yanek , L R , Trabetti , E , Lehne , B , Vozzi , D , Verbanck , M , Biino , G , Saba , Y , Meulenbelt , I , O'Connell , J R , Laakso , M , Giulianini , F , Magnusson , P K E , Ballantyne , C M , Hottenga , J J , Montgomery , G , Rivadineira , F , Rueedi , R , Steri , M , Herzig , K-H , Stott , D J , Menni , C , Franberg , M , St Pourcain , B , Felix , S B , Pers , T H , Bakker , S J L , Kraft , P , Peters , A , Vaidya , D , Delgado , G , Smit , J H , Grossmann , V , Sinisalo , J , Seppala , I , Williams , S R , Holliday , E G , Moed , M , Langenberg , C , Raikkonen , K , Ding , J , Campbell , H , Sale , M M , Chen , Y-D I , James , A L , Ruggiero , D , Soranzo , N , Hartman , C A , Smith , E N , Berenson , G S , Fuchsberger , C , Hernandez , D , Tiesler , C M T , Giedraitis , V , Liewald , D , F
Publication Year :
2018

Details

Database :
OAIster
Journal :
Ligthart , S , Vaez , A , Vosa , U , Stathopoulou , M G , de Vries , P S , Prins , B P , Van der Most , P J , Tanaka , T , Naderi , E , Rose , L M , Wu , Y , Karlsson , R , Barbalic , M , Lin , H , Pool , R , Zhu , G , Mace , A , Sidore , C , Trompet , S , Mangino , M , Sabater-Lleal , M , Kemp , J P , Abbasi , A , Kacprowski , T , Verweij , N , Smith , A V , Huang , T , Marzi , C , Feitosa , M F , Lohman , K K , Kleber , M E , Milaneschi , Y , Mueller , C , Huq , M , Vlachopoulou , E , Lyytikainen , L-P , Oldmeadow , C , Deelen , J , Perola , M , Zhao , J , Feenstra , B , Amini , M , Lahti , J , Schraut , K E , Fornage , M , Suktitipat , B , Chen , W-M , Li , X , Nutile , T , Malerba , G , Luan , J , Bak , T , Schork , N , Del Greco , F M , Thiering , E , Mahajan , A , Marioni , R E , Mihailov , E , Eriksson , J , Ozel , A B , Zhang , W , Nethander , M , Cheng , Y-C , Aslibekyan , S , Ang , W , Gandin , I , Yengo , L , Portas , L , Kooperberg , C , Hofer , E , Rajan , K B , Schurmann , C , den Hollander , W , Ahluwalia , T S , Zhao , J , Draisma , H H M , Ford , I , Timpson , N , Teumer , A , Huang , H , Wahl , S , Liu , Y , Huang , J , Uh , H-W , Geller , F , Joshi , P K , Yanek , L R , Trabetti , E , Lehne , B , Vozzi , D , Verbanck , M , Biino , G , Saba , Y , Meulenbelt , I , O'Connell , J R , Laakso , M , Giulianini , F , Magnusson , P K E , Ballantyne , C M , Hottenga , J J , Montgomery , G , Rivadineira , F , Rueedi , R , Steri , M , Herzig , K-H , Stott , D J , Menni , C , Franberg , M , St Pourcain , B , Felix , S B , Pers , T H , Bakker , S J L , Kraft , P , Peters , A , Vaidya , D , Delgado , G , Smit , J H , Grossmann , V , Sinisalo , J , Seppala , I , Williams , S R , Holliday , E G , Moed , M , Langenberg , C , Raikkonen , K , Ding , J , Campbell , H , Sale , M M , Chen , Y-D I , James , A L , Ruggiero , D , Soranzo , N , Hartman , C A , Smith , E N , Berenson , G S , Fuchsberger , C , Hernandez , D , Tiesler , C M T , Giedraitis , V , Liewald , D , F
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1322720572
Document Type :
Electronic Resource