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Transfusion transmission of hepatitis A virus with fecal shedding in a previously hepatitis A vaccinated recipient

Transfusion transmission of hepatitis A virus with fecal shedding in a previously hepatitis A vaccinated recipient

Authors :
Vestergaard, Hanne Thang
Harritshøj, Lene Holm
Midgley, Sofie Elisabeth
Ullum, Henrik
Kampmann, Peter
Vestergaard, Hanne Thang
Harritshøj, Lene Holm
Midgley, Sofie Elisabeth
Ullum, Henrik
Kampmann, Peter
Source :
Vestergaard , H T , Harritshøj , L H , Midgley , S E , Ullum , H & Kampmann , P 2018 , ' Transfusion transmission of hepatitis A virus with fecal shedding in a previously hepatitis A vaccinated recipient ' , Journal of Infection and Chemotherapy , vol. 24 , no. 9 , pp. 766-768 .
Publication Year :
2018

Abstract

We describe a rare case of hepatitis A virus (HAV) replication in feces despite presence of hepatitis A antibodies in an acute myeloid leukemia (AML) patient after transfusion with HAV contaminated platelets. The patient has been vaccinated against HAV years before the AML diagnosis. Transient infection and reshedding should thus be considered in antibody-positive hematological patients. Transfusion associated HAV transmission is rare, and little evidence exists on the clinical consequences and possible effect of treatment with immunoglobulin. Further reporting on fecal shedding despite antibodies are needed, as HAV antibody levels are used as course of action for post-exposure prophylaxis and infection control.

Details

Database :
OAIster
Journal :
Vestergaard , H T , Harritshøj , L H , Midgley , S E , Ullum , H & Kampmann , P 2018 , ' Transfusion transmission of hepatitis A virus with fecal shedding in a previously hepatitis A vaccinated recipient ' , Journal of Infection and Chemotherapy , vol. 24 , no. 9 , pp. 766-768 .
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1322716686
Document Type :
Electronic Resource