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NAD+ in Aging:Molecular Mechanisms and Translational Implications
- Source :
- Fang , E F , Lautrup , S , Hou , Y , Demarest , T G , Croteau , D L , Mattson , M P & Bohr , V A 2017 , ' NAD + in Aging : Molecular Mechanisms and Translational Implications ' , Trends in Molecular Medicine , vol. 23 , no. 10 , pp. 899-916 .
- Publication Year :
- 2017
-
Abstract
- The coenzyme NAD+ is critical in cellular bioenergetics and adaptive stress responses. Its depletion has emerged as a fundamental feature of aging that may predispose to a wide range of chronic diseases. Maintenance of NAD+ levels is important for cells with high energy demands and for proficient neuronal function. NAD+ depletion is detected in major neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cardiovascular disease and muscle atrophy. Emerging evidence suggests that NAD+ decrements occur in various tissues during aging, and that physiological and pharmacological interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases. Here, we discuss aspects of NAD+ biosynthesis, together with putative mechanisms of NAD+ action against aging, including recent preclinical and clinical trials. Recent discoveries have demonstrated an age-dependent decrease in cellular and/or tissue NAD+ levels in laboratory animal models. Moreover, NAD+ depletion has been linked to multiple hallmarks of aging. In premature aging animal models, NAD+ levels are decreased, while NAD+ replenishment can improve lifespan and healthspan through DNA repair and mitochondrial maintenance. Mitochondrial autophagy (mitophagy) has a major role in clearance of damaged and/or dysfunctional mitochondria, and compromised mitophagy has been linked to metabolic disorders, neurodegeneration [including Alzheimer's disease (AD) and Parkinson's disease (PD)] in addition to aging, and other age-related diseases. New evidence suggests that NAD+ precursors, such as nicotinamide and nicotinamide riboside, forestall pathology and cognitive decline in mouse models of AD. NAD+ supplementation can inhibit multiple aging features in animal models. This highlights essential roles for NAD+ i
Details
- Database :
- OAIster
- Journal :
- Fang , E F , Lautrup , S , Hou , Y , Demarest , T G , Croteau , D L , Mattson , M P & Bohr , V A 2017 , ' NAD + in Aging : Molecular Mechanisms and Translational Implications ' , Trends in Molecular Medicine , vol. 23 , no. 10 , pp. 899-916 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322701550
- Document Type :
- Electronic Resource