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East-West gradient in the incidence of inflammatory bowel disease in Europe:the ECCO-EpiCom inception cohort
- Source :
- Burisch , J , Pedersen , N , Čuković-Čavka , S , Brinar , M , Kaimakliotis , I , Duricova , D , Shonová , O , Vind , I , Avnstrøm , S , Thorsgaard , N , Andersen , V , Krabbe , S , Dahlerup , J F , Salupere , R , Nielsen , K R , Olsen , J , Manninen , P , Collin , P , Tsianos , E V , Katsanos , K H , Ladefoged , K , Lakatos , L , Björnsson , E , Ragnarsson , G , Bailey , Y , Odes , S , Schwartz , D , Martinato , M , Lupinacci , G , Milla , M , De Padova , A , D'Incà , R , Beltrami , M , Kupcinskas , L , Kiudelis , G , Turcan , S , Tighineanu , O , Mihu , I , Magro , F , Barros , L F , Goldis , A , Lazar , D , Belousova , E , Nikulina , I , Hernandez , V , Martinez-Ares , D , Almer , S , Zhulina , Y , Halfvarson , J , Munkholm , P & EpiCom Group 2014 , ' East-West gradient in the incidence of inflammatory bowel disease in Europe : the ECCO-EpiCom inception cohort ' , Gut , vol. 63 , no. 4 , pp. 588-597 .
- Publication Year :
- 2014
-
Abstract
- OBJECTIVE: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East-West gradient in the incidence of IBD in Europe exists.DESIGN: A prospective, uniformly diagnosed, population based inception cohort of IBD patients in 31 centres from 14 Western and eight Eastern European countries covering a total background population of approximately 10.1 million people was created. One-third of the centres had previous experience with inception cohorts. Patients were entered into a low cost, web based epidemiological database, making participation possible regardless of socioeconomic status and prior experience.RESULTS: 1515 patients aged 15 years or older were included, of whom 535 (35%) were diagnosed with Crohn's disease (CD), 813 (54%) with ulcerative colitis (UC) and 167 (11%) with IBD unclassified (IBDU). The overall incidence rate ratios in all Western European centres were 1.9 (95% CI 1.5 to 2.4) for CD and 2.1 (95% CI 1.8 to 2.6) for UC compared with Eastern European centres. The median crude annual incidence rates per 100,000 in 2010 for CD were 6.5 (range 0-10.7) in Western European centres and 3.1 (range 0.4-11.5) in Eastern European centres, for UC 10.8 (range 2.9-31.5) and 4.1 (range 2.4-10.3), respectively, and for IBDU 1.9 (range 0-39.4) and 0 (range 0-1.2), respectively. In Western Europe, 92% of CD, 78% of UC and 74% of IBDU patients had a colonoscopy performed as the diagnostic procedure compared with 90%, 100% and 96%, respectively, in Eastern Europe. 8% of CD and 1% of UC patients in both regions underwent surgery within the first 3 months of the onset of disease. 7% of CD patients and 3% of UC patients from Western Europe received biological treatment as rescue therapy. Of all European CD patients, 20% received only 5-aminosalicylates as induction therapy.CONCLUSIONS: An East-West gradient in IBD incidence
Details
- Database :
- OAIster
- Journal :
- Burisch , J , Pedersen , N , Čuković-Čavka , S , Brinar , M , Kaimakliotis , I , Duricova , D , Shonová , O , Vind , I , Avnstrøm , S , Thorsgaard , N , Andersen , V , Krabbe , S , Dahlerup , J F , Salupere , R , Nielsen , K R , Olsen , J , Manninen , P , Collin , P , Tsianos , E V , Katsanos , K H , Ladefoged , K , Lakatos , L , Björnsson , E , Ragnarsson , G , Bailey , Y , Odes , S , Schwartz , D , Martinato , M , Lupinacci , G , Milla , M , De Padova , A , D'Incà , R , Beltrami , M , Kupcinskas , L , Kiudelis , G , Turcan , S , Tighineanu , O , Mihu , I , Magro , F , Barros , L F , Goldis , A , Lazar , D , Belousova , E , Nikulina , I , Hernandez , V , Martinez-Ares , D , Almer , S , Zhulina , Y , Halfvarson , J , Munkholm , P & EpiCom Group 2014 , ' East-West gradient in the incidence of inflammatory bowel disease in Europe : the ECCO-EpiCom inception cohort ' , Gut , vol. 63 , no. 4 , pp. 588-597 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322662963
- Document Type :
- Electronic Resource