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Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes
- Source :
- Larsen , L H , Rose , C S , Sparsø , T , Overgaard , J , Torekov , S S , Grarup , N , Jensen , D P , Albrechtsen , A , Andersen , G , Ek , J , Glümer , C , Borch-Johnsen , K , Jørgensen , T , Hansen , T & Pedersen , O 2007 , ' Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes ' , International Journal of Obesity , vol. 31 , no. 2 , pp. 365-70 .
- Publication Year :
- 2007
-
Abstract
- The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.
Details
- Database :
- OAIster
- Journal :
- Larsen , L H , Rose , C S , Sparsø , T , Overgaard , J , Torekov , S S , Grarup , N , Jensen , D P , Albrechtsen , A , Andersen , G , Ek , J , Glümer , C , Borch-Johnsen , K , Jørgensen , T , Hansen , T & Pedersen , O 2007 , ' Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes ' , International Journal of Obesity , vol. 31 , no. 2 , pp. 365-70 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322621499
- Document Type :
- Electronic Resource