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Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures
- Source :
- Junker , N , Kvistborg , P , Køllgaard , T , Straten , P T , Andersen , M H & Svane , I M 2012 , ' Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures ' , Cellular Immunology , vol. 273 , no. 1 , pp. 1-9 .
- Publication Year :
- 2012
-
Abstract
- Ex vivo expanded tumor infiltrating lymphocytes (TILs) from malignant melanoma (MM) and head & neck squamous cell carcinoma (HNSCC) share a similar oligoclonal composition of T effector memory cells, with HLA class I restricted lysis of tumor cell lines. In this study we show that ex vivo expanded TILs from MM and HNSCC demonstrate a heterogeneous composition in frequency and magnitude of tumor associated antigen specific populations by Elispot IFN¿ quantitation. TILs from MM and HNSCC shared reactivity towards NY ESO-1, cyclin B1 and Bcl-x derived peptides. Additionally we show that dominating T-cell clones and functionality persists through out expansion among an oligoclonal composition of T-cells. Our findings mirror prior results on the oligoclonal composition of TIL cultures, further indicating a potential for a broader repertoire of specific effector cells recognizing the heterogeneous tumors upon adoptive transfer; increasing the probability of tumor control by minimizing immune evasion by tumor cell escape variants.
Details
- Database :
- OAIster
- Journal :
- Junker , N , Kvistborg , P , Køllgaard , T , Straten , P T , Andersen , M H & Svane , I M 2012 , ' Tumor associated antigen specific T-cell populations identified in ex vivo expanded TIL cultures ' , Cellular Immunology , vol. 273 , no. 1 , pp. 1-9 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322620697
- Document Type :
- Electronic Resource