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Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women

Authors :
Klemmensen, Ak
Tabor, A
Østerdal, M L
Knudsen, V K
Halldorsson, T I
Mikkelsen, T B
Olsen, S F
Klemmensen, Ak
Tabor, A
Østerdal, M L
Knudsen, V K
Halldorsson, T I
Mikkelsen, T B
Olsen, S F
Source :
Klemmensen , A , Tabor , A , Østerdal , M L , Knudsen , V K , Halldorsson , T I , Mikkelsen , T B & Olsen , S F 2009 , ' Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women ' , British Journal of Obstetrics and Gynecology , vol. 116 , no. 7 , pp. 964-74 .
Publication Year :
2009

Abstract

Udgivelsesdato: 2009-Jun<br />OBJECTIVE: It has been suggested that vitamin C, alone or in combination with vitamin E, may protect against pre-eclampsia, whereas the safety of high-dose vitamin E supplements has been questioned. We investigated dietary intakes of vitamins C and E to see if they correlated with the incidence of pre-eclampsia. DESIGN: Prospective cohort study. SETTING: The Danish National Birth Cohort; a population-based pregnancy cohort; analyses were based on 57 346 pregnancies. METHODS: Vitamin intake was estimated from a food frequency questionnaire completed in gestational week 25, recording intake from diet and supplements during the previous four weeks. Pre-eclampsia diagnoses were obtained from the Danish National Patient Registry; we worked with two entities, 'pre-eclampsia (all types)' and 'severe pre-eclampsia/eclampsia/HELLP'. We adjusted for confounding factors by logistic regression. MAIN OUTCOME MEASURES: A small increase in the incidence of severe disease was also seen in the group of women (64, n = 49 373) with a high intake of vitamin E from supplements and dietary sources. RESULTS: The incidence of 'pre-eclampsia (all types)' did not correlate with dietary vitamin C and E intake. There was a decreasing trend (P = 0.01) in the incidence of 'severe pre-eclampsia/eclampsia/HELLP' with increasing dietary vitamin C intake; with an intake of 130-170 mg/day as reference, odds ratios ranged from 1.21 (95% confidence interval 0.83 to 1.75) for an intake below 70 mg/day to 0.70 (0.40 to 1.23) for an intake exceeding 275 mg/day (total n = 57 346). For vitamin E intake aggregated from diet and supplements (n = 49 373), with an intake of 10.5-13.5 mg/day as reference, the 'severe pre-eclampsia/eclampsia/HELLP' odds ratio was 1.46 (1.02 to 2.09) for an intake exceeding 18 mg/day. CONCLUSIONS: Low dietary intake of vitamin C was associated with a trend towards an increased incidence of either severe pre-eclampsia, eclampsia or HELLP. A small increase in the incidence of severe

Details

Database :
OAIster
Journal :
Klemmensen , A , Tabor , A , Østerdal , M L , Knudsen , V K , Halldorsson , T I , Mikkelsen , T B & Olsen , S F 2009 , ' Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women ' , British Journal of Obstetrics and Gynecology , vol. 116 , no. 7 , pp. 964-74 .
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1322592608
Document Type :
Electronic Resource