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The impact of everolimus versus mycophenolate on blood and lymphocyte cyclosporine exposure in heart-transplant recipients

Authors :
Gustafsson, Finn
Barth, David
Delgado, Diego H
Nsouli, Meerna
Sheedy, Jill
Ross, Heather J
Gustafsson, Finn
Barth, David
Delgado, Diego H
Nsouli, Meerna
Sheedy, Jill
Ross, Heather J
Source :
Gustafsson , F , Barth , D , Delgado , D H , Nsouli , M , Sheedy , J & Ross , H J 2009 , ' The impact of everolimus versus mycophenolate on blood and lymphocyte cyclosporine exposure in heart-transplant recipients ' , European Journal of Clinical Pharmacology , vol. 65 , no. 7 , pp. 659-65 .
Publication Year :
2009

Abstract

Udgivelsesdato: 2009-Jul<br />BACKGROUND: Trough- or 2-h post-dose (C2) blood cyclosporine (CsA) concentrations are used for prediction of efficacy and toxicity of CsA in transplant recipients concomitantly treated with antiproliferative agents, but information on utility of blood CsA levels in patients treated with proliferation signal inhibitors (PSIs), such as everolimus, is sparse. Because of the inhibitory effect of PSIs on the P-glycoprotein drug efflux pump present in lymphocytes, we hypothesized that CsA pharmacokinetics in blood and lymphocytes were dissociated in patients concomitantly treated with everolimus. METHODS: Twelve-hour pharmacokinetic studies of whole-blood and intralymphocytic CsA concentrations were conducted in long-term heart-transplant recipients treated with mycophenolate mofetil (MMF) + CsA (n = 8) and everolimus + CsA (n = 9). RESULTS: There was a highly significant correlation between blood CsA C2 levels and blood CsA AUC(0-12) in groups of patients treated with MMF or everolimus (R(2) 0.93 and 0.96, respectively; P < 0.001 for both). Whereas blood CsA C2 levels were closely associated with lymphocyte CsA AUC(0-12) in patients treated with MMF (R(2) = 0.98), there was poor correlation between whole-blood C2 and lymphocyte AUC(0-12) in patients treated with everolimus (R(2) = 0.24). CONCLUSION: Standard blood CsA levels accurately predict intralymphocytic exposure to CsA in patients concomitantly treated with MMF but not in patients treated with everolimus.

Details

Database :
OAIster
Journal :
Gustafsson , F , Barth , D , Delgado , D H , Nsouli , M , Sheedy , J & Ross , H J 2009 , ' The impact of everolimus versus mycophenolate on blood and lymphocyte cyclosporine exposure in heart-transplant recipients ' , European Journal of Clinical Pharmacology , vol. 65 , no. 7 , pp. 659-65 .
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1322592353
Document Type :
Electronic Resource