IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes

Authors :: Christiansen, J.
Kolte, A.M.
Hansen, T.O.
Nielsen, F.C.
Christiansen, J.
Kolte, A.M.
Hansen, T.O.
Nielsen, F.C.
Source :: Christiansen , J , Kolte , A M , Hansen , T O & Nielsen , F C 2009 , ' IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes ' , Journal of Molecular Endocrinology , vol. 43 , no. 5 , pp. 187-195 .
Publication Year :: 2009
Abstract: Recent genome-wide association (GWA) studies of type 2 diabetes (T2D) have implicated IGF2 mRNA-binding protein 2 (IMP2/IGF2BP2) as one of the several factors in the etiology of late onset diabetes. IMP2 belongs to a family of oncofetal mRNA-binding proteins implicated in RNA localization, stability, and translation that are essential for normal embryonic growth and development. This review provides a background to the IMP protein family with an emphasis on human IMP2, followed by a closer look at the GWA studies to evaluate the significance, if any, of the proposed correlation between IMP2 and T2D Udgivelsesdato: 2009/11

Database :: OAIster
Journal :: Christiansen , J , Kolte , A M , Hansen , T O & Nielsen , F C 2009 , ' IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes ' , Journal of Molecular Endocrinology , vol. 43 , no. 5 , pp. 187-195 .
Notes :: English
Publication Type :: Electronic Resource
Accession number :: edsoai.on1322592177
Document Type :: Electronic Resource

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