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Acute P. falciparum malaria induces a loss of CD28- T IFN-¿ producing cells
- Source :
- Kemp , K , Akanmori , B D , Kurtzhals , J A L , Adabayeri , V , Goka , B Q & Hviid , L 2002 , ' Acute P. falciparum malaria induces a loss of CD28 - T IFN-¿ producing cells ' , Parasite Immunology , vol. 24 , no. 11-12 , pp. 545-8 .
- Publication Year :
- 2002
-
Abstract
- Udgivelsesdato: null-null<br />P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-gamma and IL-4 by CD28-and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-gamma producing CD28-T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.
Details
- Database :
- OAIster
- Journal :
- Kemp , K , Akanmori , B D , Kurtzhals , J A L , Adabayeri , V , Goka , B Q & Hviid , L 2002 , ' Acute P. falciparum malaria induces a loss of CD28 - T IFN-¿ producing cells ' , Parasite Immunology , vol. 24 , no. 11-12 , pp. 545-8 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322550597
- Document Type :
- Electronic Resource