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Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
- Source :
- Christensen , A F , Sørensen , G L , Hørslev-Petersen , K , Holmskov , U , Lindegaard , H M , Junker , K , Hetland , M L , Stengaard-Pedersen , K , Jacobsen , S , Lottenburger , T , Ellingsen , T , Andersen , L S , Hansen , I , Skjødt , H , Pedersen , J K , Lauridsen , U B , Svendsen , A , Tarp , U , Pødenphant , J , Vestergaard , A , Jurik , A G , Østergaard , M & Junker , P 2010 , ' Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis ' , Arthritis Research & Therapy , vol. 12 , no. 2 , pp. R39 .
- Publication Year :
- 2010
-
Abstract
- Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previously, we reported low circulating SP-D in early rheumatoid arthritis (RA), and the present investigation aims to extend these data by serial SP-D serum measurements, studies on synovial fluid, SP-D size distribution and genotyping in patients with early RA.
Details
- Database :
- OAIster
- Journal :
- Christensen , A F , Sørensen , G L , Hørslev-Petersen , K , Holmskov , U , Lindegaard , H M , Junker , K , Hetland , M L , Stengaard-Pedersen , K , Jacobsen , S , Lottenburger , T , Ellingsen , T , Andersen , L S , Hansen , I , Skjødt , H , Pedersen , J K , Lauridsen , U B , Svendsen , A , Tarp , U , Pødenphant , J , Vestergaard , A , Jurik , A G , Østergaard , M & Junker , P 2010 , ' Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis ' , Arthritis Research & Therapy , vol. 12 , no. 2 , pp. R39 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322183055
- Document Type :
- Electronic Resource