Validation of Pediatric Idiopathic Generalized Epilepsy Diagnoses from the Danish National Patient Register During 1994‒2019

Magnus Spangsberg Boesen,1 Melita Cacic Hribljan,2 Søren Kirchhoff Christensen,1 Amalie Wandel Klein-Petersen,3 Sahla El Mahdaoui,4 Malini Vendela Sagar,5 Emilie Schou,5 Anna Korsgaard Eltvedt,6 Malene Landbo Børresen,3,7 Maria Jose Miranda,6 Alfred Peter Born,3 Peter Vilhelm Uldall,3 Lau Caspar Thygesen8 1Department of Neurology, Zealand University Hospital, Roskilde, Region Zealand, Denmark; 2Department of Clinical Neurophysiology, Copenhagen University Hospital, Copenhagen, Capital Region, Denmark; 3Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Capital Region, Denmark; 4Department of Neurology, Danish Multiple Sclerosis Center, Copenhagen University Hospital, Glostrup, Capital Region, Denmark; 5Department of Neurology, Copenhagen University Hospital, Copenhagen, Capital Region, Denmark; 6Department of Paediatrics, Herlev Hospital, Herlev, Capital Region, Denmark; 7Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Capital Region, Denmark; 8National Institute of Public Health, University of Southern Denmark, Copenhagen, Capital Region, DenmarkCorrespondence: Magnus Spangsberg Boesen, Department of Neurology, Zealand University Hospital, Sygehusvej 10, Roskilde, 4000, Denmark, Tel +45 27634945, Email magnus.spangsberg.boesen@regionh.dkObjective: To identify pediatric idiopathic generalized epilepsy (IGE) during 1994– 2019 using ICD-10 codes in the Danish National Patient Register and anti-seizure prescriptions in the Danish Prescription Database.Study Design and Setting: We reviewed the medical records in children with ICD-10 codes for IGE before 18 years of age, and pediatric neurologists confirmed that the International League Against Epilepsy criteria were met. We estimated positive predictive values (PPV) and sensitivity for ICD-10 alone, including combinations of codes, anti-seizure prescription, and age at first code registration using medical record-validated diagnoses as gold standar