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Studies of Mosaicism for Chromosomal Aneuploidy in Fetal Loss Using Fluorescence In Situ Hybridization on Several Tissue Types

Studies of Mosaicism for Chromosomal Aneuploidy in Fetal Loss Using Fluorescence In Situ Hybridization on Several Tissue Types

Authors :
Marilyn Schendel
Mary Haag
John Addis
Knox, Aaron
Marilyn Schendel
Mary Haag
John Addis
Knox, Aaron
Publication Year :
1999

Abstract

The main objective ofthis study was to determine the presence and level of mosaicism for chromosomal aneuploidy in several cases of fetal demise that had previous indications of chromosome aberrations. The presence of aneuploidy was determined using fluorescence in situ hybridization (FISH) probes. Techniques that were utilized in attempts to prepare several tissue types for FISH are described. The analyses made with FISH provided useful data on the chromosomal makeup oftwo of the cases studied. In one case FISH results showed that the product of conception (POC) did not contain the trisomy 18 that is present at low levels in the mother’s blood cells. In the other case the miscarried fetus was previously identified as being mosaic for trisomy X. In this research project the presence ofvarying levels of trisomy X in both embryonic and placental tissue was confirmed

Details

Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1317661962
Document Type :
Electronic Resource