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Probing the aglycon binding site of a beta-glucosidase:a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors
- Source :
- Wrodnigg , T M , Diness , F , Gruber , C , Häusler , H , Lundt , I , Rupitz , K , Steiner , A J , Stütz , A E , Tarling , C A , Withers , S G & Wölfler , H 2004 , ' Probing the aglycon binding site of a beta-glucosidase : a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors ' , Bioorganic & Medicinal Chemistry , vol. 12 , no. 13 , pp. 3485-95 .
- Publication Year :
- 2004
-
Abstract
- A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. Ki values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/inhibitor binding.
Details
- Database :
- OAIster
- Journal :
- Wrodnigg , T M , Diness , F , Gruber , C , Häusler , H , Lundt , I , Rupitz , K , Steiner , A J , Stütz , A E , Tarling , C A , Withers , S G & Wölfler , H 2004 , ' Probing the aglycon binding site of a beta-glucosidase : a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors ' , Bioorganic & Medicinal Chemistry , vol. 12 , no. 13 , pp. 3485-95 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1316694948
- Document Type :
- Electronic Resource