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The genetic architecture of the human cerebral cortex
Authors :
Grasby, KL Jahanshad, N Painter, JN Colodro-Conde, L Bralten, J Hibar, DP Lind, PA Pizzagalli, F Ching, CRK McMahon, MAB Shatokhina, N Zsembik, LCP Thomopoulos, SI Zhu, AH Strike, LT Agartz, I Alhusaini, S Almeida, MAA Alnaes, D Amlien, IK Andersson, M Ard, T Armstrong, NJ Ashley-Koch, A Atkins, JR Bernard, M Brouwer, RM Buimer, EEL Bulow, R Burger, C Cannon, DM Chakravarty, M Chen, Q Cheung, JW Couvy-Duchesne, B Dale, AM Dalvie, S de Araujo, TK de Zubicaray, GI de Zwarte, SMC den Braber, A Nhat, TD Dohm, K Ehrlich, S Engelbrecht, H-R Erk, S Fan, CC Fedko, IO Foley, SF Ford, JM Fukunaga, M Garrett, ME Ge, T Giddaluru, S Goldman, AL Green, MJ Groenewold, NA Grotegerd, D Gurholt, TP Gutman, BA Hansell, NK Harris, MA Harrison, MB Haswell, CC Hauser, M Herms, S Heslenfeld, DJ Ho, NF Hoehn, D Hoffmann, P Holleran, L Hoogman, M Hottenga, J-J Ikeda, M Janowitz, D Jansen, IE Jia, T Jockwitz, C Kanai, R Karama, S Kasperaviciute, D Kaufmann, T Kelly, S Kikuchi, M Klein, M Knapp, M Knodt, AR Kramer, B Lam, M Lancaster, TM Lee, PH Lett, TA Lewis, LB Lopes-Cendes, I Luciano, M Macciardi, F Marquand, AF Mathias, SR Melzer, TR Milaneschi, Y Mirza-Schreiber, N Moreira, JCV Muhleisen, TW Mueller-Myhsok, B Najt, P Nakahara, S Nho, K Loohuis, LMO Orfanos, DP Pearson, JF Pitcher, TL Putz, B Quide, Y Ragothaman, A Rashid, FM Reay, WR Redlich, R Reinbold, CS Repple, J Richard, G Riedel, BC Risacher, SL Rocha, CS Mota, NR Salminen, L Saremi, A Saykin, AJ Schlag, F Schmaal, L Schofield, PR Secolin, R Shapland, CY Shen, L Shin, J Shumskaya, E Sonderby, IE Sprooten, E Tansey, KE Teumer, A Thalamuthu, A Tordesillas-Gutierrez, D Turner, JA Uhlmann, A Vallerga, CL van der Meer, D van Donkelaar, MMJ van Eijk, L van Erp, TGM van Haren, NEM van Rooij, D van Tol, M-J Veldink, JH Verhoef, E Walton, E Wang, M Wang, Y Wardlaw, JM Wen, W Westlye, LT Whelan, CD Witt, SH Wittfeld, K Wolf, C Wolfers, T Wu, JQ Yasuda, CL Zaremba, D Zhang, Z Zwiers, MP Artiges, E Assareh, AA Ayesa-Arriola, R Belger, A Brandt, CL Brown, GG Cichon, S Curran, JE Davies, GE Degenhardt, F Dennis, MF Dietsche, B Djurovic, S Doherty, CP Espiritu, R Garijo, D Gil, Y Gowland, PA Green, RC Hausler, AN Heindel, W Ho, B-C Hoffmann, WU Holsboer, F Homuth, G Hosten, N Jack, CR Jang, M Jansen, A Kimbrel, NA Kolskar, K Koops, S Krug, A Lim, KO Luykx, JJ Mathalon, DH Mather, KA Mattay, VS Matthews, S Van Son, JM McEwen, SC Melle, I Morris, DW Mueller, BA Nauck, M Nordvik, JE Noethen, MM O'Leary, DS Opel, N Martinot, M-LP Pike, GB Preda, A Quinlan, EB Rasser, PE Ratnakar, V Reppermund, S Steen, VM Tooney, PA Torres, FR Veltman, DJ Voyvodic, JT Whelan, R White, T Yamamori, H Adams, HHH Bis, JC Debette, S Decarli, C Fornage, M Gudnason, V Hofer, E Ikram, MA Launer, L Longstreth, WT Lopez, OL Mazoyer, B Mosley, TH Roshchupkin, GV Satizabal, CL Schmidt, R Seshadri, S Yang, Q Alvim, MKM Ames, D Anderson, TJ Andreassen, OA Arias-Vasquez, A Bastin, ME Baune, BT Beckham, JC Blangero, J Boomsma, DI Brodaty, H Brunner, HG Buckner, RL Buitelaar, JK Bustillo, JR Cahn, W Cairns, MJ Calhoun, V Carr, VJ Caseras, X Caspers, S Cavalleri, GL Cendes, F Corvin, A Crespo-Facorro, B Dalrymple-Alford, JC Dannlowski, U de Geus, EJC Deary, IJ Delanty, N Depondt, C Desrivieres, S Donohoe, G Espeseth, T Fernandez, G Fisher, SE Flor, H Forstner, AJ Francks, C Franke, B Glahn, DC Gollub, RL Grabe, HJ Gruber, O Haberg, AK Hariri, AR Hartman, CA Hashimoto, R Heinz, A Henskens, FA Hillegers, MHJ Hoekstra, PJ Holmes, AJ Hong, LE Hopkins, WD Pol, HEH Jernigan, TL Jonsson, EG Kahn, RS Kennedy, MA Kircher, TTJ Kochunov, P Kwok, JBJ Le Hellard, S Loughland, CM Martin, NG Martinot, J-L McDonald, C McMahon, KL Meyer-Lindenberg, A Michie, PT Morey, RA Mowry, B Nyberg, L Oosterlaan, J Ophoff, RA Pantelis, C Paus, T Pausova, Z Penninx, BWJH Polderman, TJC Posthuma, D Rietschel, M Roffman, JL Rowland, LM Sachdev, PS Samann, PG Schall, U Schumann, G Scott, RJ Sim, K Sisodiya, SM Smoller, JW Sommer, IE St Pourcain, B Stein, DJ Toga, AW Trollor, JN Van der Wee, NJA van't Ent, D Volzke, H Walter, H Weber, B Weinberger, DR Wright, MJ Zhou, J Stein, JL Thompson, PM Medland, SE Grasby, KL Jahanshad, N Painter, JN Colodro-Conde, L Bralten, J Hibar, DP Lind, PA Pizzagalli, F Ching, CRK McMahon, MAB Shatokhina, N Zsembik, LCP Thomopoulos, SI Zhu, AH Strike, LT Agartz, I Alhusaini, S Almeida, MAA Alnaes, D Amlien, IK Andersson, M Ard, T Armstrong, NJ Ashley-Koch, A Atkins, JR Bernard, M Brouwer, RM Buimer, EEL Bulow, R Burger, C Cannon, DM Chakravarty, M Chen, Q Cheung, JW Couvy-Duchesne, B Dale, AM Dalvie, S de Araujo, TK de Zubicaray, GI de Zwarte, SMC den Braber, A Nhat, TD Dohm, K Ehrlich, S Engelbrecht, H-R Erk, S Fan, CC Fedko, IO Foley, SF Ford, JM Fukunaga, M Garrett, ME Ge, T Giddaluru, S Goldman, AL Green, MJ Groenewold, NA Grotegerd, D Gurholt, TP Gutman, BA Hansell, NK Harris, MA Harrison, MB Haswell, CC Hauser, M Herms, S Heslenfeld, DJ Ho, NF Hoehn, D Hoffmann, P Holleran, L Hoogman, M Hottenga, J-J Ikeda, M Janowitz, D Jansen, IE Jia, T Jockwitz, C Kanai, R Karama, S Kasperaviciute, D Kaufmann, T Kelly, S Kikuchi, M Klein, M Knapp, M Knodt, AR Kramer, B Lam, M Lancaster, TM Lee, PH Lett, TA Lewis, LB Lopes-Cendes, I Luciano, M Macciardi, F Marquand, AF Mathias, SR Melzer, TR Milaneschi, Y Mirza-Schreiber, N Moreira, JCV Muhleisen, TW Mueller-Myhsok, B Najt, P Nakahara, S Nho, K Loohuis, LMO Orfanos, DP Pearson, JF Pitcher, TL Putz, B Quide, Y Ragothaman, A Rashid, FM Reay, WR Redlich, R Reinbold, CS Repple, J Richard, G Riedel, BC Risacher, SL Rocha, CS Mota, NR Salminen, L Saremi, A Saykin, AJ Schlag, F Schmaal, L Schofield, PR Secolin, R Shapland, CY Shen, L Shin, J Shumskaya, E Sonderby, IE Sprooten, E Tansey, KE Teumer, A Thalamuthu, A Tordesillas-Gutierrez, D Turner, JA Uhlmann, A Vallerga, CL van der Meer, D van Donkelaar, MMJ van Eijk, L van Erp, TGM van Haren, NEM van Rooij, D van Tol, M-J Veldink, JH Verhoef, E Walton, E Wang, M Wang, Y Wardlaw, JM Wen, W Westlye, LT Whelan, CD Witt, SH Wittfeld, K Wolf, C Wolfers, T Wu, JQ Yasuda, CL Zaremba, D Zhang, Z Zwiers, MP Artiges, E Assareh, AA Ayesa-Arriola, R Belger, A Brandt, CL Brown, GG Cichon, S Curran, JE Davies, GE Degenhardt, F Dennis, MF Dietsche, B Djurovic, S Doherty, CP Espiritu, R Garijo, D Gil, Y Gowland, PA Green, RC Hausler, AN Heindel, W Ho, B-C Hoffmann, WU Holsboer, F Homuth, G Hosten, N Jack, CR Jang, M Jansen, A Kimbrel, NA Kolskar, K Koops, S Krug, A Lim, KO Luykx, JJ Mathalon, DH Mather, KA Mattay, VS Matthews, S Van Son, JM McEwen, SC Melle, I Morris, DW Mueller, BA Nauck, M Nordvik, JE Noethen, MM O'Leary, DS Opel, N Martinot, M-LP Pike, GB Preda, A Quinlan, EB Rasser, PE Ratnakar, V Reppermund, S Steen, VM Tooney, PA Torres, FR Veltman, DJ Voyvodic, JT Whelan, R White, T Yamamori, H Adams, HHH Bis, JC Debette, S Decarli, C Fornage, M Gudnason, V Hofer, E Ikram, MA Launer, L Longstreth, WT Lopez, OL Mazoyer, B Mosley, TH Roshchupkin, GV Satizabal, CL Schmidt, R Seshadri, S Yang, Q Alvim, MKM Ames, D Anderson, TJ Andreassen, OA Arias-Vasquez, A Bastin, ME Baune, BT Beckham, JC Blangero, J Boomsma, DI Brodaty, H Brunner, HG Buckner, RL Buitelaar, JK Bustillo, JR Cahn, W Cairns, MJ Calhoun, V Carr, VJ Caseras, X Caspers, S Cavalleri, GL Cendes, F Corvin, A Crespo-Facorro, B Dalrymple-Alford, JC Dannlowski, U de Geus, EJC Deary, IJ Delanty, N Depondt, C Desrivieres, S Donohoe, G Espeseth, T Fernandez, G Fisher, SE Flor, H Forstner, AJ Francks, C Franke, B Glahn, DC Gollub, RL Grabe, HJ Gruber, O Haberg, AK Hariri, AR Hartman, CA Hashimoto, R Heinz, A Henskens, FA Hillegers, MHJ Hoekstra, PJ Holmes, AJ Hong, LE Hopkins, WD Pol, HEH Jernigan, TL Jonsson, EG Kahn, RS Kennedy, MA Kircher, TTJ Kochunov, P Kwok, JBJ Le Hellard, S Loughland, CM Martin, NG Martinot, J-L McDonald, C McMahon, KL Meyer-Lindenberg, A Michie, PT Morey, RA Mowry, B Nyberg, L Oosterlaan, J Ophoff, RA Pantelis, C Paus, T Pausova, Z Penninx, BWJH Polderman, TJC Posthuma, D Rietschel, M Roffman, JL Rowland, LM Sachdev, PS Samann, PG Schall, U Schumann, G Scott, RJ Sim, K Sisodiya, SM Smoller, JW Sommer, IE St Pourcain, B Stein, DJ Toga, AW Trollor, JN Van der Wee, NJA van't Ent, D Volzke, H Walter, H Weber, B Weinberger, DR Wright, MJ Zhou, J Stein, JL Thompson, PM Medland, SE
Publication Year :
2020
Abstract
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
Details
Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315703582
Document Type :
Electronic Resource