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Novel genetic loci associated with hippocampal volume
Authors :
Hibar, DP Adams, HHH Jahanshad, N Chauhan, G Stein, JL Hofer, E Renteria, ME Bis, JC Arias-Vasquez, A Ikram, MK Desrivieres, S Vernooij, MW Abramovic, L Alhusaini, S Amin, N Andersson, M Arfanakis, K Aribisala, BS Armstrong, NJ Athanasiu, L Axelsson, T Beecham, AH Beiser, A Bernard, M Blanton, SH Bohlken, MM Boks, MP Bralten, J Brickman, AM Carmichael, O Chakravarty, MM Chen, Q Ching, CRK Chouraki, V Cuellar-Partida, G Crivello, F Den Braber, A Nhat, TD Ehrlich, S Giddaluru, S Goldman, AL Gottesman, RF Grimm, O Griswold, ME Guadalupe, T Gutman, BA Hass, J Haukvik, UK Hoehn, D Holmes, AJ Hoogman, M Janowitz, D Jia, T Jorgensen, KN Karbalai, N Kasperaviciute, D Kim, S Klein, M Kraemer, B Lee, PH Liewald, DCM Lopez, LM Luciano, M Macare, C Marquand, AF Matarin, M Mather, KA Mattheisen, M McKay, DR Milaneschi, Y Maniega, SM Nho, K Nugent, AC Nyquist, P Loohuis, LMO Oosterlaan, J Papmeyer, M Pirpamer, L Puetz, B Ramasamy, A Richards, JS Risacher, SL Roiz-Santianez, R Rommelse, N Ropele, S Rose, EJ Royle, NA Rundek, T Saemann, PG Saremi, A Satizabal, CL Schmaal, L Schork, AJ Shen, L Shin, J Shumskaya, E Smith, AV Sprooten, E Strike, LT Teumer, A Tordesillas-Gutierrez, D Toro, R Trabzuni, D Trompet, S Vaidya, D Van der Grond, J Van der Lee, SJ Van der Meer, D Van Donkelaar, MMJ Van Eijk, KR Van Erp, TGM Van Rooij, D Walton, E Westlye, LT Whelan, CD Windham, BG Winkler, AM Wittfeld, K Woldehawariat, G Wolf, C Wolfers, T Yanek, LR Yang, J Zijdenbos, A Zwiers, MP Agartz, I Almasy, L Ames, D Amouyel, P Andreassen, OA Arepalli, S Assareh, AA Barral, S Bastin, ME Becker, DM Becker, JT Bennett, DA Blangero, J van Bokhoven, H Boomsma, DI Brodaty, H Brouwer, RM Brunner, HG Buckner, RL Buitelaar, JK Bulayeva, KB Cahn, W Calhoun, VD Cannon, DM Cavalleri, GL Cheng, C-Y Cichon, S Cookson, MR Corvin, A Crespo-Facorro, B Curran, JE Czisch, M Dale, AM Davies, GE De Craen, AJM De Geus, EJC De Jager, PL De Zubicaray, GI Deary, IJ Debette, S DeCarli, C Delanty, N Depondt, C DeStefano, A Dillman, A Djurovic, S Donohoe, G Drevets, WC Duggirala, R Dyer, TD Enzinger, C Erk, S Espeseth, T Fedko, IO Fernandez, G Ferrucci, L Fisher, SE Fleischman, DA Ford, I Fornage, M Foroud, TM Fox, PT Francks, C Fukunaga, M Gibbs, JR Glahn, DC Gollub, RL Goring, HHH Green, RC Gruber, O Gudnason, V Guelfi, S Haberg, AK Hansell, NK Hardy, J Hartman, CA Hashimoto, R Hegenscheid, K Heinz, A Le Hellard, S Hernandez, DG Heslenfeld, DJ Ho, B-C Hoekstra, PJ Hoffmann, W Hofman, A Holsboer, F Homuth, G Hosten, N Hottenga, J-J Huentelman, M Pol, HEH Ikeda, M Jack, CR Jenkinson, M Johnson, R Joensson, EG Jukema, JW Kahn, RS Kanai, R Kloszewska, I Knopman, DS Kochunov, P Kwok, JB Lawrie, SM Lemaitre, H Liu, X Longo, DL Lopez, OL Lovestone, S Martinez, O Martinot, J-L Mattay, VS McDonald, C McIntosh, AM McMahon, FJ McMahon, KL Mecocci, P Melle, I Meyer-Lindenberg, A Mohnke, S Montgomery, GW Morris, DW Mosley, TH Muhleisen, TW Mueller-Myhsok, B Nalls, MA Nauck, M Nichols, TE Niessen, WJ Nothen, MM Nyberg, L Ohi, K Olvera, RL Ophoff, RA Pandolfo, M Paus, T Pausova, Z Penninx, BWJH Pike, GB Potkin, SG Psaty, BM Reppermund, S Rietschel, M Roffman, JL Romanczuk-Seiferth, N Rotter, JI Ryten, M Sacco, RL Sachdev, PS Saykin, AJ Schmidt, R Schmidt, H Schofield, PR Sigursson, S Simmons, A Singleton, A Sisodiya, SM Smith, C Smoller, JW Soininen, H Steen, VM Stott, DJ Sussmann, JE Thalamuthu, A Toga, AW Traynor, BJ Troncoso, J Tsolaki, M Tzourio, C Uitterlinden, AG Hernandez, MCV Van der Brug, M van der Lugt, A van der Wee, NJA Van Haren, NEM van't Ent, D Van Tol, M-J Vardarajan, BN Vellas, B Veltman, DJ Voelzke, H Walter, H Wardlaw, JM Wassink, TH Weale, ME Weinberger, DR Weiner, MW Wen, W Westman, E White, T Wong, TY Wright, CB Zielke, RH Zonderman, AB Martin, NG Van Duijn, CM Wright, MJ Longstreth, WT Schumann, G Grabe, HJ Franke, B Launer, LJ Medland, SE Seshadri, S Thompson, PM Ikram, MA Hibar, DP Adams, HHH Jahanshad, N Chauhan, G Stein, JL Hofer, E Renteria, ME Bis, JC Arias-Vasquez, A Ikram, MK Desrivieres, S Vernooij, MW Abramovic, L Alhusaini, S Amin, N Andersson, M Arfanakis, K Aribisala, BS Armstrong, NJ Athanasiu, L Axelsson, T Beecham, AH Beiser, A Bernard, M Blanton, SH Bohlken, MM Boks, MP Bralten, J Brickman, AM Carmichael, O Chakravarty, MM Chen, Q Ching, CRK Chouraki, V Cuellar-Partida, G Crivello, F Den Braber, A Nhat, TD Ehrlich, S Giddaluru, S Goldman, AL Gottesman, RF Grimm, O Griswold, ME Guadalupe, T Gutman, BA Hass, J Haukvik, UK Hoehn, D Holmes, AJ Hoogman, M Janowitz, D Jia, T Jorgensen, KN Karbalai, N Kasperaviciute, D Kim, S Klein, M Kraemer, B Lee, PH Liewald, DCM Lopez, LM Luciano, M Macare, C Marquand, AF Matarin, M Mather, KA Mattheisen, M McKay, DR Milaneschi, Y Maniega, SM Nho, K Nugent, AC Nyquist, P Loohuis, LMO Oosterlaan, J Papmeyer, M Pirpamer, L Puetz, B Ramasamy, A Richards, JS Risacher, SL Roiz-Santianez, R Rommelse, N Ropele, S Rose, EJ Royle, NA Rundek, T Saemann, PG Saremi, A Satizabal, CL Schmaal, L Schork, AJ Shen, L Shin, J Shumskaya, E Smith, AV Sprooten, E Strike, LT Teumer, A Tordesillas-Gutierrez, D Toro, R Trabzuni, D Trompet, S Vaidya, D Van der Grond, J Van der Lee, SJ Van der Meer, D Van Donkelaar, MMJ Van Eijk, KR Van Erp, TGM Van Rooij, D Walton, E Westlye, LT Whelan, CD Windham, BG Winkler, AM Wittfeld, K Woldehawariat, G Wolf, C Wolfers, T Yanek, LR Yang, J Zijdenbos, A Zwiers, MP Agartz, I Almasy, L Ames, D Amouyel, P Andreassen, OA Arepalli, S Assareh, AA Barral, S Bastin, ME Becker, DM Becker, JT Bennett, DA Blangero, J van Bokhoven, H Boomsma, DI Brodaty, H Brouwer, RM Brunner, HG Buckner, RL Buitelaar, JK Bulayeva, KB Cahn, W Calhoun, VD Cannon, DM Cavalleri, GL Cheng, C-Y Cichon, S Cookson, MR Corvin, A Crespo-Facorro, B Curran, JE Czisch, M Dale, AM Davies, GE De Craen, AJM De Geus, EJC De Jager, PL De Zubicaray, GI Deary, IJ Debette, S DeCarli, C Delanty, N Depondt, C DeStefano, A Dillman, A Djurovic, S Donohoe, G Drevets, WC Duggirala, R Dyer, TD Enzinger, C Erk, S Espeseth, T Fedko, IO Fernandez, G Ferrucci, L Fisher, SE Fleischman, DA Ford, I Fornage, M Foroud, TM Fox, PT Francks, C Fukunaga, M Gibbs, JR Glahn, DC Gollub, RL Goring, HHH Green, RC Gruber, O Gudnason, V Guelfi, S Haberg, AK Hansell, NK Hardy, J Hartman, CA Hashimoto, R Hegenscheid, K Heinz, A Le Hellard, S Hernandez, DG Heslenfeld, DJ Ho, B-C Hoekstra, PJ Hoffmann, W Hofman, A Holsboer, F Homuth, G Hosten, N Hottenga, J-J Huentelman, M Pol, HEH Ikeda, M Jack, CR Jenkinson, M Johnson, R Joensson, EG Jukema, JW Kahn, RS Kanai, R Kloszewska, I Knopman, DS Kochunov, P Kwok, JB Lawrie, SM Lemaitre, H Liu, X Longo, DL Lopez, OL Lovestone, S Martinez, O Martinot, J-L Mattay, VS McDonald, C McIntosh, AM McMahon, FJ McMahon, KL Mecocci, P Melle, I Meyer-Lindenberg, A Mohnke, S Montgomery, GW Morris, DW Mosley, TH Muhleisen, TW Mueller-Myhsok, B Nalls, MA Nauck, M Nichols, TE Niessen, WJ Nothen, MM Nyberg, L Ohi, K Olvera, RL Ophoff, RA Pandolfo, M Paus, T Pausova, Z Penninx, BWJH Pike, GB Potkin, SG Psaty, BM Reppermund, S Rietschel, M Roffman, JL Romanczuk-Seiferth, N Rotter, JI Ryten, M Sacco, RL Sachdev, PS Saykin, AJ Schmidt, R Schmidt, H Schofield, PR Sigursson, S Simmons, A Singleton, A Sisodiya, SM Smith, C Smoller, JW Soininen, H Steen, VM Stott, DJ Sussmann, JE Thalamuthu, A Toga, AW Traynor, BJ Troncoso, J Tsolaki, M Tzourio, C Uitterlinden, AG Hernandez, MCV Van der Brug, M van der Lugt, A van der Wee, NJA Van Haren, NEM van't Ent, D Van Tol, M-J Vardarajan, BN Vellas, B Veltman, DJ Voelzke, H Walter, H Wardlaw, JM Wassink, TH Weale, ME Weinberger, DR Weiner, MW Wen, W Westman, E White, T Wong, TY Wright, CB Zielke, RH Zonderman, AB Martin, NG Van Duijn, CM Wright, MJ Longstreth, WT Schumann, G Grabe, HJ Franke, B Launer, LJ Medland, SE Seshadri, S Thompson, PM Ikram, MA
Publication Year :
2017
Abstract
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Details
Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315692653
Document Type :
Electronic Resource