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Synthesis of deoxycytidine oligomers containing phosphorodithioate linkages
- Source :
- Grandas , A , Marshall , W S , Nielsen , J & Caruthers , M H 1989 , ' Synthesis of deoxycytidine oligomers containing phosphorodithioate linkages ' , Tetrahedron Letters , vol. 30 , no. 5 , pp. 543-546 .
- Publication Year :
- 1989
-
Abstract
- Deoxydicytidine phosphoramidite, 4-chlorobenzylmercaptan and tetrazole reacted to form dinucleoside thiophosphite. Oxidation with sulfur yields phosphorodithioates which were used to synthesize pentadecadeoxyoligonucleotides containing nuclease resistant phosphorodithioate internucleotide linkages.
Details
- Database :
- OAIster
- Journal :
- Grandas , A , Marshall , W S , Nielsen , J & Caruthers , M H 1989 , ' Synthesis of deoxycytidine oligomers containing phosphorodithioate linkages ' , Tetrahedron Letters , vol. 30 , no. 5 , pp. 543-546 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1314856770
- Document Type :
- Electronic Resource