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Fuzzy logic point of view applied to diseases caused by dynamic mutations

Authors :
Savić, A.
Jovanović, K.
Mihailović, J.
Radotić, Ksenija
Savić, A.
Jovanović, K.
Mihailović, J.
Radotić, Ksenija
Source :
12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee
Publication Year :
2011

Abstract

For the first time, this paper tries to explain the origins of diseases caused by unstable DNA repeats, known as dynamic mutations. It is common to find fairly simplified correlation between the number of DNA repeats and severity of diseases. By examining the case studies, it is possible to see that simplified model does not reflect real condition of the patients, so we have proposed more complex model which involves gender, immunological condition, age of onset and analysis of family tree. Conclusions are related to known molecular biology phenomenon such as DNA methylation, histone binding and RNA secondary structure.

Details

Database :
OAIster
Journal :
12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee
Notes :
12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee
Publication Type :
Electronic Resource
Accession number :
edsoai.on1314834771
Document Type :
Electronic Resource