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Economic evaluation of endometrial scratching before the second IVF/ICSI treatment:a cost-effectiveness analysis of a randomized controlled trial (SCRaTCH trial)

Authors :
van Hoogenhuijze, N. E.
van Eekelen, R.
Mol, F.
Schipper, I.
Groenewoud, E. R.
Traas, M. A.F.
Janssen, C. A.H.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R. H.F.
Maas, J. W.M.
Moll, E.
Fleischer, K.
van Hooff, M. H.A.
de Koning, C. H.
Cantineau, A. E.P.
Lambalk, C. B.
Verberg, M.
van Heusden, A. M.
Manger, A. P.
van Rumste, M. M.E.
van der Voet, L. F.
Pieterse, Q. D.
Visser, J.
Brinkhuis, E. A.
den Hartog, J. E.
Glas, M. W.
Klijn, N. F.
van der Zanden, M.
Bandell, M. L.
Boxmeer, J. C.
van Disseldorp, J.
Smeenk, J.
van Wely, M.
Eijkemans, M. J.C.
Torrance, H. L.
Broekmans, F. J.M.
van Hoogenhuijze, N. E.
van Eekelen, R.
Mol, F.
Schipper, I.
Groenewoud, E. R.
Traas, M. A.F.
Janssen, C. A.H.
Teklenburg, G.
de Bruin, J. P.
van Oppenraaij, R. H.F.
Maas, J. W.M.
Moll, E.
Fleischer, K.
van Hooff, M. H.A.
de Koning, C. H.
Cantineau, A. E.P.
Lambalk, C. B.
Verberg, M.
van Heusden, A. M.
Manger, A. P.
van Rumste, M. M.E.
van der Voet, L. F.
Pieterse, Q. D.
Visser, J.
Brinkhuis, E. A.
den Hartog, J. E.
Glas, M. W.
Klijn, N. F.
van der Zanden, M.
Bandell, M. L.
Boxmeer, J. C.
van Disseldorp, J.
Smeenk, J.
van Wely, M.
Eijkemans, M. J.C.
Torrance, H. L.
Broekmans, F. J.M.
Source :
van Hoogenhuijze , N E , van Eekelen , R , Mol , F , Schipper , I , Groenewoud , E R , Traas , M A F , Janssen , C A H , Teklenburg , G , de Bruin , J P , van Oppenraaij , R H F , Maas , J W M , Moll , E , Fleischer , K , van Hooff , M H A , de Koning , C H , Cantineau , A E P , Lambalk , C B , Verberg , M , van Heusden , A M , Manger , A P , van Rumste , M M E , van der Voet , L F , Pieterse , Q D , Visser , J , Brinkhuis , E A , den Hartog , J E , Glas , M W , Klijn , N F , van der Zanden , M , Bandell , M L , Boxmeer , J C , van Disseldorp , J , Smeenk , J , van Wely , M , Eijkemans , M J C , Torrance , H L & Broekmans , F J M 2022 , ' Economic evaluation of endometrial scratching before the second IVF/ICSI treatment : a cost-effectiveness analysis of a randomized controlled trial (SCRaTCH trial) ' , Human reproduction (Oxford, England) , vol. 37 , no. 2 , pp. 254-263 .
Publication Year :
2022

Abstract

STUDY QUESTION: Is a single endometrial scratch prior to the second fresh IVF/ICSI treatment cost-effective compared to no scratch, when evaluated over a 12-month follow-up period? SUMMARY ANSWER: The incremental cost-effectiveness ratio (ICER) for an endometrial scratch was €6524 per additional live birth, but due to uncertainty regarding the increase in live birth rate this has to be interpreted with caution. WHAT IS KNOWN ALREADY: Endometrial scratching is thought to improve the chances of success in couples with previously failed embryo implantation in IVF/ICSI treatment. It has been widely implemented in daily practice, despite the lack of conclusive evidence of its effectiveness and without investigating whether scratching allows for a cost-effective method to reduce the number of IVF/ICSI cycles needed to achieve a live birth. STUDY DESIGN, SIZE, DURATION: This economic evaluation is based on a multicentre randomized controlled trial carried out in the Netherlands (SCRaTCH trial) that compared a single scratch prior to the second IVF/ICSI treatment with no scratch in couples with a failed full first IVF/ICSI cycle. Follow-up was 12 months after randomization.Economic evaluation was performed from a healthcare and societal perspective by taking both direct medical costs and lost productivity costs into account. It was performed for the primary outcome of biochemical pregnancy leading to live birth after 12 months of follow-up as well as the secondary outcome of live birth after the second fresh IVF/ICSI treatment (i.e. the first after randomization). To allow for worldwide interpretation of the data, cost level scenario analysis and sensitivity analysis was performed. PARTICIPANTS/MATERIALS, SETTING, METHODS: From January 2016 until July 2018, 933 women with a failed first IVF/ICSI cycle were included in the trial. Data on treatment and pregnancy were recorded up until 12 months after randomization, and the resulting live birth outcomes (even if after 12 mo

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Database :
OAIster
Journal :
van Hoogenhuijze , N E , van Eekelen , R , Mol , F , Schipper , I , Groenewoud , E R , Traas , M A F , Janssen , C A H , Teklenburg , G , de Bruin , J P , van Oppenraaij , R H F , Maas , J W M , Moll , E , Fleischer , K , van Hooff , M H A , de Koning , C H , Cantineau , A E P , Lambalk , C B , Verberg , M , van Heusden , A M , Manger , A P , van Rumste , M M E , van der Voet , L F , Pieterse , Q D , Visser , J , Brinkhuis , E A , den Hartog , J E , Glas , M W , Klijn , N F , van der Zanden , M , Bandell , M L , Boxmeer , J C , van Disseldorp , J , Smeenk , J , van Wely , M , Eijkemans , M J C , Torrance , H L & Broekmans , F J M 2022 , ' Economic evaluation of endometrial scratching before the second IVF/ICSI treatment : a cost-effectiveness analysis of a randomized controlled trial (SCRaTCH trial) ' , Human reproduction (Oxford, England) , vol. 37 , no. 2 , pp. 254-263 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1313640287
Document Type :
Electronic Resource

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