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Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil:An observational cohort study
- Source :
- Leonhard , S E , Halstead , S , Lant , S B , Militão de Albuquerque , M D F P , de Brito , C A A , de Albuquerque , L B B , Ellul , M A , de Oliveira França , R F , Gourlay , D , Griffiths , M J , de Miranda Henriques-Souza , A M , de Morais Machado , M , Medialdea-Carrera , R , Mehta , R , da Paz Melo , R , Mesquita , S D , Moreira , Á J P , Pena , L J , Santos , M L , Turtle , L , Solomon , T , Willison , H J , Jacobs , B C & Brito Ferreira , M L 2021 , ' Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil : An observational cohort study ' , Journal of the Neurological Sciences , vol. 420 , 117272 .
- Publication Year :
- 2021
-
Abstract
- Objective: To determine the clinical phenotype of Guillain-Barré syndrome (GBS) after Zika virus (ZIKV) infection, the anti-glycolipid antibody signature, and the role of other circulating arthropod-borne viruses, we describe a cohort of GBS patients identified during ZIKV and chikungunya virus (CHIKV) outbreaks in Northeast Brazil. Methods: We prospectively recruited GBS patients from a regional neurology center in Northeast Brazil between December 2014 and February 2017. Serum and CSF were tested for ZIKV, CHIKV, and dengue virus (DENV), by RT-PCR and antibodies, and serum was tested for GBS-associated antibodies to glycolipids. Results: Seventy-one patients were identified. Forty-eight (68%) had laboratory evidence of a recent arbovirus infection; 25 (52%) ZIKV, 8 (17%) CHIKV, 1 (2%) DENV, and 14 (29%) ZIKV and CHIKV. Most patients with a recent arbovirus infection had motor and sensory symptoms (72%), a demyelinating electrophysiological subtype (67%) and a facial palsy (58%). Patients with a recent infection with ZIKV and CHIKV had a longer hospital admission and more frequent mechanical ventilation compared to the other patients. No specific anti-glycolipid antibody signature was identified in association with arbovirus infection, although significant antibody titres to GM1, GalC, LM1, and GalNAc-GD1a were found infrequently. Conclusion: A large proportion of cases had laboratory evidence of a recent infection with ZIKV or CHIKV, and recent infection with both viruses was found in almost one third of patients. Most patients with a recent arbovirus infection had a sensorimotor, demyelinating GBS. We did not find a specific anti-glycolipid antibody signature in association with arbovirus-related GBS.
Details
- Database :
- OAIster
- Journal :
- Leonhard , S E , Halstead , S , Lant , S B , Militão de Albuquerque , M D F P , de Brito , C A A , de Albuquerque , L B B , Ellul , M A , de Oliveira França , R F , Gourlay , D , Griffiths , M J , de Miranda Henriques-Souza , A M , de Morais Machado , M , Medialdea-Carrera , R , Mehta , R , da Paz Melo , R , Mesquita , S D , Moreira , Á J P , Pena , L J , Santos , M L , Turtle , L , Solomon , T , Willison , H J , Jacobs , B C & Brito Ferreira , M L 2021 , ' Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil : An observational cohort study ' , Journal of the Neurological Sciences , vol. 420 , 117272 .
- Notes :
- application/pdf, application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1313631228
- Document Type :
- Electronic Resource