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Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant
- Source :
- Kamburova , E G , Wisse , B W , Joosten , I , Allebes , WA , Meer , A , Hilbrands , LB , Baas , M C , Spierings , E , Hack , CE , van Reekum , F E , van Zuilen , AD , Verhaar , MC , Bots , ML , Drop , A , Plaisier , L , Seelen , MAJ , Sanders , JSF , Hepkema , BG , Lambeck , AJA , Bungener , LB , Roozendaal , C , Tilanus , MGJ , Voorter , CE , Wieten , L , van Duijnhoven , E M , Gelens , M , Christiaans , MHL , van Ittersum , FJ , Nurmohamed , SA , Lardy , NM , Swelsen , W , van der Pant , K A , van der Weerd , NC , ten Berge , IJM , Bemelman , FJ , Hoitsma , A , van der Boog , P J M , de Fijter , JW , Betjes , M G H , Heidt , S , Roelen , DL , Claas , FH & Otten , HG 2018 , ' Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant ' , American Journal of Transplantation , vol. 18 , no. 9 , pp. 2274-2284 .
- Publication Year :
- 2018
-
Abstract
- The presence of donor-specific anti-HLA antibodies (DSAs) is associated with increased risk of graft failure after kidney transplant. We hypothesized that DSAs against HLA class I, class II, or both classes indicate a different risk for graft loss between deceased and living donor transplant. In this study, we investigated the impact of pretransplant DSAs, by using single antigen bead assays, on long-term graft survival in 3237 deceased and 1487 living donor kidney transplants with a negative complement-dependent crossmatch. In living donor transplants, we found a limited effect on graft survival of DSAs against class I or II antigens after transplant. Class I and II DSAs combined resulted in decreased 10-year graft survival (84% to 75%). In contrast, after deceased donor transplant, patients with class I or class II DSAs had a 10-year graft survival of 59% and 60%, respectively, both significantly lower than the survival for patients without DSAs (76%). The combination of class I and II DSAs resulted in a 10-year survival of 54% in deceased donor transplants. In conclusion, class I and II DSAs are a clear risk factor for graft loss in deceased donor transplants, while in living donor transplants, class I and II DSAs seem to be associated with an increased risk for graft failure, but this could not be assessed due to their low prevalence.
Details
- Database :
- OAIster
- Journal :
- Kamburova , E G , Wisse , B W , Joosten , I , Allebes , WA , Meer , A , Hilbrands , LB , Baas , M C , Spierings , E , Hack , CE , van Reekum , F E , van Zuilen , AD , Verhaar , MC , Bots , ML , Drop , A , Plaisier , L , Seelen , MAJ , Sanders , JSF , Hepkema , BG , Lambeck , AJA , Bungener , LB , Roozendaal , C , Tilanus , MGJ , Voorter , CE , Wieten , L , van Duijnhoven , E M , Gelens , M , Christiaans , MHL , van Ittersum , FJ , Nurmohamed , SA , Lardy , NM , Swelsen , W , van der Pant , K A , van der Weerd , NC , ten Berge , IJM , Bemelman , FJ , Hoitsma , A , van der Boog , P J M , de Fijter , JW , Betjes , M G H , Heidt , S , Roelen , DL , Claas , FH & Otten , HG 2018 , ' Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant ' , American Journal of Transplantation , vol. 18 , no. 9 , pp. 2274-2284 .
- Notes :
- application/pdf, und
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1313624125
- Document Type :
- Electronic Resource