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y New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
- Source :
- Lu , YC , Day , FR , Gustafsson , S , Buchkovich , ML , Na , JB , Bataille , V , Cousminer , DL , Dastani , Z , Drong , AW , Esko , T , Evans , DM , Falchi , M , Feitosa , MF , Ferreira , T , Hedman , AK , Haring , R , Hysi , PG , Iles , MM , Justice , AE , Kanoni , S , Lagou , V , Li , R , Li , X , Locke , A , Lu , C , Magi , R , Perry , JRB , Pers , TH , Qi , QB , Sanna , M , Schmidt , EM , Scott , WR , Shungin , D , Teumer , A , Vinkhuyzen , AAE , Walker , RW , Westra , HJ , Zhang , MF , Zhang , WH , Zhao , JH , Zhu , ZH , Afzal , U , Ahluwalia , TS , Bakker , SJL , Bellis , C , Bonnefond , A , Borodulin , K , Buchman , AS , Cederholm , T , Choh , AC , Choi , HJ , Curran , JE , de Groot , LCPGM , De Jager , PL , Dhonukshe-Rutten , RAM , Enneman , A , Eury , E , Evans , DS , Forsen , T , Friedrich , N , Fumeron , F , Garcia , ME , Gartner , S , Han , BG , Havulinna , AS , Hayward , C , Hernandez , D , Hillege , H , Ittermann , T , Kent , JW , Kolcic , I , Laatikainen , T , Lahti , J , Leach , IM , Lee , CG , Lee , JY , Liu , T , Liu , YF , Lobbens , S , Loh , M , Lyytikainen , LP , Medina-Gomez , C , Michaelsson , K , Nalls , MA , Nielson , CM , Oozageer , L , Pascoe , L , Paternoster , L , Polasek , O , Ripatti , S , Sarzynski , MA , Shin , CS , Narancic , NS , Spira , D , Srikanth , P , Steinhagen-Thiessen , E , Sung , YJ , Swart , KMA , Taittonen , L , Tanaka , T , Tikkanen , E , van der Velde , N , Schoor , NM , Verweij , N , Wright , AF , Yu , L , Zmuda , JM , Eklund , N , Forrester , T , Grarup , N , Jackson , AU , Kristiansson , K , Kuulasmaa , T , Kuusisto , J , Lichtner , P , Luan , JA , Mahajan , A , Mannisto , S , Palmer , CD , Ried , JS , Scott , RA , Stancakova , A , Wagner , PJ , Demirkan , A , Doring , A , Gudnason , V , Kiel , DP , Kuhnel , B , Mangino , M , McKnight , B , Menni , C , O'Connell , JR , Oostra , B , Shuldiner , AR , Song , KJ , Vandenput , L , Duijn , C , Vollenweider , P , White , CC , Boehnke , M , Boettcher , Y , Cooper , RS , For
- Publication Year :
- 2016
-
Abstract
- To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Details
- Database :
- OAIster
- Journal :
- Lu , YC , Day , FR , Gustafsson , S , Buchkovich , ML , Na , JB , Bataille , V , Cousminer , DL , Dastani , Z , Drong , AW , Esko , T , Evans , DM , Falchi , M , Feitosa , MF , Ferreira , T , Hedman , AK , Haring , R , Hysi , PG , Iles , MM , Justice , AE , Kanoni , S , Lagou , V , Li , R , Li , X , Locke , A , Lu , C , Magi , R , Perry , JRB , Pers , TH , Qi , QB , Sanna , M , Schmidt , EM , Scott , WR , Shungin , D , Teumer , A , Vinkhuyzen , AAE , Walker , RW , Westra , HJ , Zhang , MF , Zhang , WH , Zhao , JH , Zhu , ZH , Afzal , U , Ahluwalia , TS , Bakker , SJL , Bellis , C , Bonnefond , A , Borodulin , K , Buchman , AS , Cederholm , T , Choh , AC , Choi , HJ , Curran , JE , de Groot , LCPGM , De Jager , PL , Dhonukshe-Rutten , RAM , Enneman , A , Eury , E , Evans , DS , Forsen , T , Friedrich , N , Fumeron , F , Garcia , ME , Gartner , S , Han , BG , Havulinna , AS , Hayward , C , Hernandez , D , Hillege , H , Ittermann , T , Kent , JW , Kolcic , I , Laatikainen , T , Lahti , J , Leach , IM , Lee , CG , Lee , JY , Liu , T , Liu , YF , Lobbens , S , Loh , M , Lyytikainen , LP , Medina-Gomez , C , Michaelsson , K , Nalls , MA , Nielson , CM , Oozageer , L , Pascoe , L , Paternoster , L , Polasek , O , Ripatti , S , Sarzynski , MA , Shin , CS , Narancic , NS , Spira , D , Srikanth , P , Steinhagen-Thiessen , E , Sung , YJ , Swart , KMA , Taittonen , L , Tanaka , T , Tikkanen , E , van der Velde , N , Schoor , NM , Verweij , N , Wright , AF , Yu , L , Zmuda , JM , Eklund , N , Forrester , T , Grarup , N , Jackson , AU , Kristiansson , K , Kuulasmaa , T , Kuusisto , J , Lichtner , P , Luan , JA , Mahajan , A , Mannisto , S , Palmer , CD , Ried , JS , Scott , RA , Stancakova , A , Wagner , PJ , Demirkan , A , Doring , A , Gudnason , V , Kiel , DP , Kuhnel , B , Mangino , M , McKnight , B , Menni , C , O'Connell , JR , Oostra , B , Shuldiner , AR , Song , KJ , Vandenput , L , Duijn , C , Vollenweider , P , White , CC , Boehnke , M , Boettcher , Y , Cooper , RS , For
- Notes :
- application/pdf, und
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1313620501
- Document Type :
- Electronic Resource